Multiple Choice
Carbamazepine has a Black Box Warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
A) Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B*1502 allele
B) Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
C) Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele
D) Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine
Correct Answer:

Verified
Correct Answer:
Verified
Q1: A genetic variation in how the metabolite
Q2: Ultra-rapid metabolizers of drugs may have:<br>A) To
Q3: Genetic polymorphisms account for differences in metabolism,
Q5: Warfarin resistance may be seen in patients
Q6: A provider may consider testing for CYP2D6
Q7: Patients who have a poor metabolism phenotype
Q8: Rifampin is a nonspecific CYP450 inducer that
Q9: Up to 21% of Asians are ultra-rapid
Q10: Inhibition of P-glycoprotein by a drug such
Q11: Pharmacogenetic testing is required by the U.S.