RFLP Linkage Analysis Followed by Chromosome Walking Is Used to Find

Multiple Choice

RFLP linkage analysis followed by chromosome walking is used to find disease-causing genes. Which of the following would be a good indication that the disease-causing gene has been found by this analysis?

A) The gene is at least one cM from the RFLP.
B) The gene is homozygous in the affected individual.
C) The gene contains a nonsense mutation.
D) The gene is heterozygous in the individual.
E) The gene contains numerous polymorphisms.