Accessibility of DNA to Trans-Acting Molecules Is, in General, Reduced

Multiple Choice

Accessibility of DNA to trans-acting molecules is, in general, reduced by its being packaged into a nucleosome core, both in vitro and in vivo. A prominent exception to this is the behavior of:

A) The TATA box-binding protein, TBP, which binds within the minor groove.
B) Retrovirus proviral DNA, which integrates within the major groove.
C) Topoisomerase II, which binds to the sugar-phosphate backbone.
D) SV40 large T-antigen, which binds to the major groove.
E) None of the above.