Which of the Following Is a Disadvantage of Shotgun Sequencing

Multiple Choice

Which of the following is a disadvantage of shotgun sequencing as compared to hierarchical sequencing?

A) Shotgun sequencing requires a more detailed genetic map.
B) Shotgun sequencing requires the use of bacterial artificial chromosomes.
C) Shotgun sequencing is more expensive.
D) Shotgun sequencing relies more on careful aligning of DNA fragments.
E) None of the above