Conjugate Vaccines, Such as Those Developed Against H

Multiple Choice

Conjugate vaccines, such as those developed against H. influenzae type B and N. meningitidis type C, provide protection in small children and infants that are unable to make antibody responses to isolated polysaccharide antigens. However, one group of individuals that would generate antibody responses to the purified polysaccharide vaccine that are as effective as the antibodies they would make in response to the conjugate vaccine is:

A) Older individuals, such as those over the age of 50
B) Infants with X-linked SCID
C) Individuals with X-linked agammaglobulinemia
D) Individuals with hyper-IgM syndrome due to CD40-ligand deficiency
E) Individuals with chronic granulomatous disease due to deficiencies in integrin expression