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As of 2014, a Total of 452 Clinical Studies of Peptide-Based

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As of 2014, a total of 452 clinical studies of peptide-based vaccines were registered with the US federal government clinical trials database. Of these, none have progressed to market, and only a small number (12) made it to phase III clinical trials; furthermore, of these phase III trials, none were for vaccines directed against infectious diseases. The lack of success of peptide vaccines against pathogenic infections is due to the fact that antibodies against a single epitope on a pathogen are rarely protective.

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