10) a Mouse Model for Autoimmune Hemolytic Anemia Can Be

Multiple Choice

10) A mouse model for autoimmune hemolytic anemia can be transferred to naive mice by a single injection of anti-red blood cell IgG antibodies. However, the disease is prevented if recipient mice lack IgG-binding Fc receptors. These data indicate:

A) An essential role for NK cells, neutrophils and other granulocytes, and macrophages in red blood cell destruction
B) An essential role for the transport of IgG out of the blood into the tissues for red blood cell destruction
C) A critical role for innate immune cells in the development of autoreactive antibody-secreting B cells
D) That phagocytosis of antibody-coated red blood cells is only mechanism leading to red blood cell destruction
E) Autoantibodies can traffic to the bone marrow and destroy erythroid progenitor cells