In the Cases of Some Infections, Such as Mice Infected

Multiple Choice

In the cases of some infections, such as mice infected with adenovirus, the generation of effector cytotoxic CD8 T cell responses needed to clear the infection is dependent on the antigen-presenting dendritic cells receiving stimulation through the CD40 receptor on their surface, a process known as dendritic cell 'licensing'. In this infection system, the dendritic cell would likely receive CD40 receptor stimulation from:

A) The activation of a TLR expressed in the dendritic cell
B) The up-regulation of CD40 ligand by virus-infected host cells
C) The activation of cytosolic nucleic acid sensors in the dendritic cell
D) The interaction with a CD4 effector cell expressing CD40 ligand
E) The phagocytosis of apoptotic cell debris resulting from the virus infection