In Different Mammalian Species, the Ratio of B Cells Expressing $\kappa$

Multiple Choice

In different mammalian species, the ratio of B cells expressing $\kappa$ versus $\lambda$ light chain-containing antibodies is about 65%:35%. In other species, such as mice, this ratio is vastly different, at 95%:5%. If a routine blood test performed on an individual revealed that their $\lambda$ -expressing versus $\lambda$ -expressing B cells were seen at a ratio of 95%:5%, this would likely indicate that the individual had:

A) An increased number of functional V $\kappa$ gene segments compared to the average human in the population
B) A defect in allelic exclusion of antibody light chain genes
C) A defect in isotypic exclusion of antibody light chains
D) A lymphoproliferative disorder
E) A genetic defect in one of their two $\lambda$ light chain alleles