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An Important Mechanism for Generating Diversity in Immunoglobulin Light Chain

Question 16

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An important mechanism for generating diversity in immunoglobulin light chain V-region sequences is based on the fact that the RAG recombinase generates hairpin structures, rather than blunt ends, at the cleavage sites between the recombination signal sequences and the coding sequences. Explain how this mechanism generates diversity at the junctions.

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P-nucleotides are added to the junctions...

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