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For Immunoglobulin Heavy and Light Chain Genes, and for T-Cell β\beta

Question 13

Multiple Choice

For immunoglobulin heavy and light chain genes, and for T-cell receptor β\beta chain genes, there are a large number of V gene segments, and relatively few J and/or D segments that rearrange to form the final coding sequence for each gene. The TCR α\alpha locus is different in this regard, and this difference is thought to reflect the fact that nearly all α\alpha : β\beta T-cell receptors recognize a peptide bound to an MHC molecule. This unique feature of the T-cell receptor α\alpha locus is:


A) The presence of only five different V α\alpha gene segments
B) The presence of two different C α\alpha coding sequences
C) The presence of over sixty different J α\alpha gene segments
D) The absence of D gene segments
E) The large sequence distance separating the V α\alpha gene segments from the J α\alpha gene segments

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