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Phenylephrine (PE, See the Structure Below) Is a Nasal Decongestant

Question 28

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Phenylephrine (PE, see the structure below) is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) . This conjugate acid of phenylephrine (PEH) has a pKa 5.5. At a physiological pH of 7.4, what is the ratio of concentrations, [PE]/[PEH]? Phenylephrine (PE, see the structure below)  is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) . This conjugate acid of phenylephrine (PEH<font face= symbol ><sup></sup></font>)  has a pK<sub>a </sub><font face= symbol ></font> 5.5. At a physiological pH of 7.4, what is the ratio of concentrations, [PE]/[PEH<font face= symbol ><sup></sup></font>]?   A) 6.7 B) 0.01 C) 0.14 D) 79 E) 21


A) 6.7
B) 0.01
C) 0.14
D) 79
E) 21

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