How Might a Change of One Amino Acid at a Site

Multiple Choice

How might a change of one amino acid at a site, distant from the active site of an enzyme, alter the substrate specificity of an enzyme?

A) by changing the stability of the enzyme
B) by changing the three-dimensional conformation of the enzyme
C) by changing the optimum pH for the enzyme
D) by changing the binding site for a noncompetitive inhibitor