In Early Dorsoventral Patterning Studies, Researchers Found That Transplanting a Notochord

Essay

In early dorsoventral patterning studies, researchers found that transplanting a notochord from another embryo was sufficient to induce the expression of floor plate markers and motor neuron markers in a chick embryonic spinal cord explant (Figure Q7-6). What are some experiment(s) that could provide evidence that Shh is the specific signal that is both necessary and sufficient for the induction of ventral cell fates such as motor neurons? Figure Q7-6