Essay
TrkB knockout mice die early in postnatal life due to an inability to feed.
A. In the current model for neurotrophin and receptor function, pro-neurotrophins have high affinity for p75NTR, while mature neurotrophins act through one or more Trk receptors. Based on Figure Q7-22, would you expect a BDNF knockout mouse to have a more or less severe phenotype than the TrkB knockout? Briefly explain your reasoning. 
Figure Q7-22
B. Now consider the observation that many, perhaps most, neurons that express TrkB also express TrkA or TrkC. How does this alter your prediction?
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