Exam 15: Paramyxoviruses and Rhabdoviruses

There are two sequence elements at the 3' end of the genomes of paramyxoviruses that are required for mRNA transcription and genome replication.These two sequences are 78 nucleotides apart.How can the polymerase bind to both of these sequence elements at the same time?

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Question 1

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Which of the following is a difference observed between the paramyxoviruses and the rhabdoviruses?

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Describe two major differences between transcription and genome replication in paramyxoviruses.

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When the levels of the nucleocapsid protein builds up in the infected cell,the viral polymerase switches from producing subgenomic mRNAs to producing full-length positive-strand antigenomes.One major difference is that the nucleocapsid protein only binds and encapsidates the full-length antigenome and genome copies.The subgenomic mRNAs are not bound by the nucleocapsid protein.The second major difference is that during genome replication the viral RNA polymerase does not pause at the intergenic regions and stutter to create the polyA tail.It continues through and produces an authentic full-length copy of the genome with no stops or reinitiation.

What is the function of the neuraminidase enzyme during infection with Sendai virus,a member of the paramyxovirus family?

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Question 4

Subacute sclerosing panencephalitis (SSPE)is a common complication of measles where the virus infects the nervous tissue immediately after causing the typical measles virus symptoms.

(True/False)

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Question 5

The order of the genes in the genomes of paramyxoviruses and rhabdoviruses is highly conserved.Is there a benefit to the virus for this specific gene order?

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Question 6

All of the following viruses are members of the order Mononegavirales EXCEPT….

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Question 7

Mutation of the RNA editing site in the genome of a paramyxovirus will have which of the following effects?

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Question 8

Most of the genomes of the paramyxoviruses have been shown to have genomes lengths that are exact multiple of 8 nucleotides.

(True/False)

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Question 9

New paramyxoviruses have emerged from fruit bats by being transmitted to domestic livestock and then to humans.

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Question 10

Which of the following virion proteins mediates the coiling of the rhabdovirus nucleocapsid to form the bullet-shaped virion?

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Question 11

The F protein of the paramyxovirus measles is responsible for both binding and fusion of the virion to the host cell.

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Question 12

Because measles virus can infect B and T lymphocytes,it can lead to strong immunosuppression.

(True/False)

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Question 13

Which of the following conditions during infection with a paramyxovirus causes the RNA-dependent RNA polymerase to switch from start-stop transcription to production of full-length positive-strand antigenomes?

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Question 14

Synthesis of mRNAs in paramyxoviruses occurs through a single-entry mechanism,which is where the RNA-dependent RNA polymerase can only start transcription from the 3' end of the genome.Which of the following is a consequence of this mechanism?

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Question 15

Which of the following proteins from paramyxovirus virions interacts with the tails of the envelope glycoproteins during assembly of virions?

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Question 16

What mechanism do the paramyxoviruses use to produce 5 different proteins from a single gene on their genome?

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Question 17

How is the poly(A)tail added to the 3' ends of the mRNAs produced during infection with a paramyxovirus?

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Question 18

Rhabdoviruses can infect a wide variety of hosts including insects,plants and vertebrates.

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Question 19

Describe the two models that explain how the monopartite negative-strand RNA viruses produces individual mRNAs.Which of the two models does the experimental evidence support?

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Question 20

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Exam 15: Paramyxoviruses and Rhabdoviruses

There are two sequence elements at the 3' end of the genomes of paramyxoviruses that are required for mRNA transcription and genome replication.These two sequences are 78 nucleotides apart.How can the polymerase bind to both of these sequence elements at the same time?

Which of the following is a difference observed between the paramyxoviruses and the rhabdoviruses?

Describe two major differences between transcription and genome replication in paramyxoviruses.

What is the function of the neuraminidase enzyme during infection with Sendai virus,a member of the paramyxovirus family?

Subacute sclerosing panencephalitis (SSPE)is a common complication of measles where the virus infects the nervous tissue immediately after causing the typical measles virus symptoms.

The order of the genes in the genomes of paramyxoviruses and rhabdoviruses is highly conserved.Is there a benefit to the virus for this specific gene order?

All of the following viruses are members of the order Mononegavirales EXCEPT….

Mutation of the RNA editing site in the genome of a paramyxovirus will have which of the following effects?

Most of the genomes of the paramyxoviruses have been shown to have genomes lengths that are exact multiple of 8 nucleotides.

New paramyxoviruses have emerged from fruit bats by being transmitted to domestic livestock and then to humans.

Which of the following virion proteins mediates the coiling of the rhabdovirus nucleocapsid to form the bullet-shaped virion?

The F protein of the paramyxovirus measles is responsible for both binding and fusion of the virion to the host cell.

Because measles virus can infect B and T lymphocytes,it can lead to strong immunosuppression.

Which of the following conditions during infection with a paramyxovirus causes the RNA-dependent RNA polymerase to switch from start-stop transcription to production of full-length positive-strand antigenomes?

Synthesis of mRNAs in paramyxoviruses occurs through a single-entry mechanism,which is where the RNA-dependent RNA polymerase can only start transcription from the 3' end of the genome.Which of the following is a consequence of this mechanism?

Which of the following proteins from paramyxovirus virions interacts with the tails of the envelope glycoproteins during assembly of virions?

What mechanism do the paramyxoviruses use to produce 5 different proteins from a single gene on their genome?

How is the poly(A)tail added to the 3' ends of the mRNAs produced during infection with a paramyxovirus?

Rhabdoviruses can infect a wide variety of hosts including insects,plants and vertebrates.

Describe the two models that explain how the monopartite negative-strand RNA viruses produces individual mRNAs.Which of the two models does the experimental evidence support?

Introduction to Virology 2

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Virus Classification: the World of Viruses

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