Question 1

The nucleocapsid describes the structure that includes the:

Accepted Answer

A) capsid and the genome 
B) capsid and the envelope 
C) envelope and the glycoproteins 
D) helical capsid and an envelope 
E) icosahedral capsid and an envelope 
A) capsid and the genome 
B) capsid and the envelope 
C) envelope and the glycoproteins 
D) helical capsid and an envelope 
E) icosahedral capsid and an envelope A

Question 2

Which of the following is NOT a characteristic of a regular icosahedron?

Accepted Answer

A) It has 12 vertices of 5-fold symmetry. 
B) It has 20 triangular faces. 
C) It has 20 sides with 3-fold symmetry. 
D) It has 30 edges with 2-fold symmetry 
E) It has 6 square faces. 
A) It has 12 vertices of 5-fold symmetry. 
B) It has 20 triangular faces. 
C) It has 20 sides with 3-fold symmetry. 
D) It has 30 edges with 2-fold symmetry 
E) It has 6 square faces. E

Question 3

It is possible to get high resolution images of enveloped virus particles using x-ray diffraction.

Accepted Answer

A) True 
 B)False  False

Question 4

Which of the following h and k values will produce a triangulation number of 13?

Accepted Answer

A) 1 and 1 
B) 1 and 2 
C) 1 and 3 
D) 2 and 3 
E) 2 and 4 
A) 1 and 1 
B) 1 and 2 
C) 1 and 3 
D) 2 and 3 
E) 2 and 4

Question 5

Viral envelopes often have very different lipid compositions than the cellular membranes that they originate from.

Accepted Answer

Quasi-equivalence describes the situatio

Question 6

Enveloped virions assemble and acquire their envelope by which of the following mechanisms?

Accepted Answer

A) The nucleocapsids interact directly with the cytoplasmic tails of the envelope glycoproteins and bud through the cellular membrane. 
B) The nucleocapsids interact with the matrix protein,which interact with the cytoplasmic tails of the envelope glycoprotein,and the virion buds through the cellular membrane. 
C) The envelope is assembled de novo around the nucleocapsid by cellular enzymes. 
D) The virion acquires the envelope after it leaves the host cell from extracellular vesicles. 
E) Both a and b are used by viruses. 
A) The nucleocapsids interact directly with the cytoplasmic tails of the envelope glycoproteins and bud through the cellular membrane. 
B) The nucleocapsids interact with the matrix protein,which interact with the cytoplasmic tails of the envelope glycoprotein,and the virion buds through the cellular membrane. 
C) The envelope is assembled de novo around the nucleocapsid by cellular enzymes. 
D) The virion acquires the envelope after it leaves the host cell from extracellular vesicles. 
E) Both a and b are used by viruses.

Question 7

Some viruses particles have a rigid capsid surrounding an internal membrane.

Accepted Answer

A) True 
 B)False

Question 8

In a helical nucleocapsid,which of the following MOST affects the LENGTH of the capsid?

Accepted Answer

A) the $\mu$ (mu)value 
B) the $\rho$ (rho)value 
C) the size of the genome and the P (pitch)of the helix 
D) the size of the capsid protein 
E) None of the above. 
A) the $\mu$ (mu)value 
B) the $\rho$ (rho)value 
C) the size of the genome and the P (pitch)of the helix 
D) the size of the capsid protein 
E) None of the above.

Question 9

Most viruses that use a spherical shaped capsid arrange their capsid proteins with which of the following symmetries?

Accepted Answer

A) cubic 
B) tetrahedral 
C) icosahedral 
D) dodecagon 
E) helical 
A) cubic 
B) tetrahedral 
C) icosahedral 
D) dodecagon 
E) helical

Question 10

Depending on the type of virus,which of the following is a function of the virus capsid?

Accepted Answer

A) To attach to the correct type of host cell. 
B) To protect the viral genome from nucleases. 
C) To ensure delivery of the genome into the host cell. 
D) To protect the viral genome from damage by UV light. 
E) All of the above functions are correct. 
A) To attach to the correct type of host cell. 
B) To protect the viral genome from nucleases. 
C) To ensure delivery of the genome into the host cell. 
D) To protect the viral genome from damage by UV light. 
E) All of the above functions are correct.

Question 11

Which of the following describes the number of subunits per turn in a helical capsid?

Accepted Answer

A) P (pitch) 
B) $\mu$ (mu) 
C) $\rho$(rho) 
D) Triangulation number 
E) symmetry 
A) P (pitch) 
B) $\mu$ (mu) 
C) $\rho$(rho) 
D) Triangulation number 
E) symmetry

Question 12

Virions are often described as being energetically "metastable".What does this mean and why is it important for entry and uncoating of the viral genome into the next host cell?

Accepted Answer

Virons are described as "metastable" bec

Question 13

The Jelly Roll $\beta$ barrel is:

Accepted Answer

A) a structure found in many viral envelope glycoproteins. 
B) a structure found in many viral capsid proteins. 
C) the structure the viral genome takes inside of a helical capsid. 
D) the structure the viral genome takes inside an icosahedral capsid. 
E) the structure of many helical capsids as the wrap around the genome. 
A) a structure found in many viral envelope glycoproteins. 
B) a structure found in many viral capsid proteins. 
C) the structure the viral genome takes inside of a helical capsid. 
D) the structure the viral genome takes inside an icosahedral capsid. 
E) the structure of many helical capsids as the wrap around the genome.

Question 14

A packaging sequence is involved in which of the following assembly processes?

Accepted Answer

A) The assembly of the capsid around the genomic nucleic acid. 
B) The correct binding of capsid proteins to each other. 
C) The insertion of the viral glycoproteins in the envelope. 
D) The acquisition of the envelope by the capsid. 
E) The packaging of the matrix proteins into the virion. 
A) The assembly of the capsid around the genomic nucleic acid. 
B) The correct binding of capsid proteins to each other. 
C) The insertion of the viral glycoproteins in the envelope. 
D) The acquisition of the envelope by the capsid. 
E) The packaging of the matrix proteins into the virion.

Question 15

The capsid of SV40 contains 360 protein copies.Why is this unusual?

Accepted Answer

A) There is only 1 kind of protein in this capsid. 
B) 360 is not the correct number of protein capsids for a T = 6 capsid. 
C) Six is not a mathematically allowed triangulation number. 
D) The proteins have equivalent interactions. 
E) The capsid is not large enough to hold the entire genome. 
A) There is only 1 kind of protein in this capsid. 
B) 360 is not the correct number of protein capsids for a T = 6 capsid. 
C) Six is not a mathematically allowed triangulation number. 
D) The proteins have equivalent interactions. 
E) The capsid is not large enough to hold the entire genome.

Question 16

Cryoelectron microscopy uses computer reconstruction of images of multiple virions to produce a high resolution image of a virion or capsid.

Accepted Answer

A) True 
 B)False

Question 17

A very common structure for bacteriophage particles is which of the following?

Accepted Answer

A) an icosahedral head and an envelope 
B) a naked icosahedral head 
C) a naked helical tail 
D) an icosahedral head with a helical tail 
E) a cubic head with a helical tail 
A) an icosahedral head and an envelope 
B) a naked icosahedral head 
C) a naked helical tail 
D) an icosahedral head with a helical tail 
E) a cubic head with a helical tail

Question 18

A scaffolding protein is important for assembly of an icosahedral capsid…..

Accepted Answer

A) but does not bind to the viral genome. 
B) but does not become part of the final virion. 
C) and helps to cut the genome into unit lengths. 
D) and binds to the host cell receptor. 
E) and assists the virion in exiting the host cell. 
A) but does not bind to the viral genome. 
B) but does not become part of the final virion. 
C) and helps to cut the genome into unit lengths. 
D) and binds to the host cell receptor. 
E) and assists the virion in exiting the host cell.

Question 19

Which of the following is a description of a scaffolding protein?

Accepted Answer

A) A cellular protein that acts as a chaperone during assembly of a helical capsid. 
B) A viral protein that is used on the outside of an icosahedral capsid during assembly. 
C) A viral protein used on the inside of an icosahedral capsid during assembly and then removed. 
D) A protease that trims the proteins during assembly of an icosahedral capsid. 
E) A energy dependent motor used to package the genome into larger icosahedral capsids. 
A) A cellular protein that acts as a chaperone during assembly of a helical capsid. 
B) A viral protein that is used on the outside of an icosahedral capsid during assembly. 
C) A viral protein used on the inside of an icosahedral capsid during assembly and then removed. 
D) A protease that trims the proteins during assembly of an icosahedral capsid. 
E) A energy dependent motor used to package the genome into larger icosahedral capsids.

Question 20

How many copies of the capsid protein would there be in an icosahedral capsid with a Triangulation number of 7?

Accepted Answer

A) 70 
B) 210 
C) 280 
D) 420 
E) 490 
A) 70 
B) 210 
C) 280 
D) 420 
E) 490

Exam 2: Virus Structure and Assembly

The nucleocapsid describes the structure that includes the:

Which of the following is NOT a characteristic of a regular icosahedron?

It is possible to get high resolution images of enveloped virus particles using x-ray diffraction.

Which of the following h and k values will produce a triangulation number of 13?

Viral envelopes often have very different lipid compositions than the cellular membranes that they originate from.

Enveloped virions assemble and acquire their envelope by which of the following mechanisms?

Some viruses particles have a rigid capsid surrounding an internal membrane.

In a helical nucleocapsid,which of the following MOST affects the LENGTH of the capsid?

Most viruses that use a spherical shaped capsid arrange their capsid proteins with which of the following symmetries?

Depending on the type of virus,which of the following is a function of the virus capsid?

Which of the following describes the number of subunits per turn in a helical capsid?

Virions are often described as being energetically "metastable".What does this mean and why is it important for entry and uncoating of the viral genome into the next host cell?

The Jelly Roll β\betaβ barrel is:

A packaging sequence is involved in which of the following assembly processes?

The capsid of SV40 contains 360 protein copies.Why is this unusual?

Cryoelectron microscopy uses computer reconstruction of images of multiple virions to produce a high resolution image of a virion or capsid.

A very common structure for bacteriophage particles is which of the following?

A scaffolding protein is important for assembly of an icosahedral capsid…..

Which of the following is a description of a scaffolding protein?

How many copies of the capsid protein would there be in an icosahedral capsid with a Triangulation number of 7?

Introduction to Virology 2

Virus Classification: the World of Viruses

Virus Entry

Single-Stranded Rna Bacteriophages

Microviruses

Bacteriophage

Bacteriophage Lambda

Viruses of Archaea

Cucumber Mosaic Virus

Picornaviruses

Flaviviruses

Togaviruses

Coronaviruses

Paramyxoviruses and Rhabdoviruses

Filovirouses

Bunyaviruses

Influenza Viruses

Reoviruses

Parvoviruses

Polyomaviruses

Papillomaviruses

Adenoviruses

Herpesviruses

Baculoviruses

Poxviruses

Viruses of Algae and Mimivirus

Retroviruses

Human Immunodeficiency Virus

Hepadnaviruses

Viroids and Hepatitis Delta Virus

Prions

Intrinsic Cellular Defenses Against Virus Infection

Innate and Adaptive Immune Responses to Virus Infection

Antiviral Vaccines

Antiviral Chemotherapy

Eukaryotic Virus Vectors

Filters

The Jelly Roll $\beta$ barrel is: