Question 1

Which of the following components in the complement cascade mediates the lysis of the target cells?

Accepted Answer

A)  C1qrs 
B)  C4a, C3a, and C5a 
C)  C5 to C9 
D)  C3a and C3b 
A)  C1qrs 
B)  C4a, C3a, and C5a 
C)  C5 to C9 
D)  C3a and C3b

Question 2

MATCHING
Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once.
-Has the highest serum concentration

Accepted Answer

A) IgA 
B) IgM 
C) IgG 
D) IgE 
A) IgA 
B) IgM 
C) IgG 
D) IgE

Question 3

An antigen that originates from the individual is termed:

Accepted Answer

A)  autologous. 
B)  allogeneic. 
C)  hapten. 
D)  immunogen. 
A)  autologous. 
B)  allogeneic. 
C)  hapten. 
D)  immunogen.

Question 4

What immunoglobulin class is capable of crossing the placenta?

Accepted Answer

A)  IgM 
B)  IgA 
C)  IgE 
D)  IgG 
A)  IgM 
B)  IgA 
C)  IgE 
D)  IgG

Question 5

What part of the immunoglobulin molecule distinguishes the isotype?

Accepted Answer

A)  Light chain 
B)  Heavy chain 
C)  Kappa chain 
D)  Lambda chain 
A)  Light chain 
B)  Heavy chain 
C)  Kappa chain 
D)  Lambda chain

Question 6

An antibody identified in the transfusion service appeared to be reacting stronger following the second exposure to an antigen from a transfusion.The most likely explanation of this observation is:

Accepted Answer

A)  affinity maturation of the immunoglobulin molecule. 
B)  anamnestic response. 
C)  isotype switching. 
D)  All of the above 
A)  affinity maturation of the immunoglobulin molecule. 
B)  anamnestic response. 
C)  isotype switching. 
D)  All of the above

Question 7

MATCHING
Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once.
-Has the highest number of antigen binding sites

Accepted Answer

A) IgA 
B) IgM 
C) IgG 
D) IgE 
A) IgA 
B) IgM 
C) IgG 
D) IgE

Question 8

Select the substance that regulates the activity of other cells by binding to specific receptors.

Accepted Answer

A)  Cytokines 
B)  Complement 
C)  Immunoglobulins 
D)  Anaphylatoxin 
A)  Cytokines 
B)  Complement 
C)  Immunoglobulins 
D)  Anaphylatoxin

Question 9

What portion of the antibody molecule binds to receptors on macrophages and assists in the removal of antibody bound to red cells?

Accepted Answer

A)  Fab fragment 
B)  Hinge region 
C)  Fc fragment 
D)  J chain 
A)  Fab fragment 
B)  Hinge region 
C)  Fc fragment 
D)  J chain

Question 10

After adding antigen and antibody to a test tube,one large agglutinate was observed.How should this reaction be graded?

Accepted Answer

A)  2+ 
B)  3+ 
C)  4+ 
D)  0 
A)  2+ 
B)  3+ 
C)  4+ 
D)  0

Question 11

Select the term that describes cells or tissue from a genetically different individual within the same species.

Accepted Answer

A)  Allogeneic 
B)  Autologous 
C)  Xenogeneic 
D)  Autograft 
A)  Allogeneic 
B)  Autologous 
C)  Xenogeneic 
D)  Autograft

Question 12

Which of the following requires adjustment in order to enhance the reaction of an antibody in vitro?

Accepted Answer

A)  Temperature above 37° C 
B)  Speed of the centrifuge above the calibrated settings 
C)  Increase the concentration of red cells in the test system 
D)  Increase the incubation time in the incubator 
A)  Temperature above 37° C 
B)  Speed of the centrifuge above the calibrated settings 
C)  Increase the concentration of red cells in the test system 
D)  Increase the incubation time in the incubator

Question 13

When testing for the A antigen in a patient,what would you use to perform the test?

Accepted Answer

A)  Patient's plasma and commercial A red cells 
B)  Commercial A cells and anti-A 
C)  Patient's red cells and anti-A 
D)  None of the above 
A)  Patient's plasma and commercial A red cells 
B)  Commercial A cells and anti-A 
C)  Patient's red cells and anti-A 
D)  None of the above

Question 14

Which of the following is responsible for the activation of the classic pathway of complement?

Accepted Answer

A)  Bacteria 
B)  Foreign proteins 
C)  Virus 
D)  Antibody bound to antigen 
A)  Bacteria 
B)  Foreign proteins 
C)  Virus 
D)  Antibody bound to antigen

Question 15

Select the term from the list below that best fits the definitions.
-Variable region of an immunoglobulin

Accepted Answer

A) Kappa 
B) Epitope 
C) Hinge region 
D) Isotype 
E) Idiotype 
A) Kappa 
B) Epitope 
C) Hinge region 
D) Isotype 
E) Idiotype

Question 16

In a serologic test,the term prozone is also known as:

Accepted Answer

A)  equivalence. 
B)  antigen excess. 
C)  antibody excess. 
D)  serum-to-cell ratio. 
A)  equivalence. 
B)  antigen excess. 
C)  antibody excess. 
D)  serum-to-cell ratio.

Question 17

Select the region of the antibody molecule responsible for imparting unique antibody specificity.

Accepted Answer

A)  Variable region 
B)  Constant region 
C)  Hinge region 
D)  Fc fragment 
A)  Variable region 
B)  Constant region 
C)  Hinge region 
D)  Fc fragment

Question 18

What immunoglobulin class reacts best at room temperature at immediate-spin?

Accepted Answer

A)  IgM 
B)  IgA 
C)  IgE 
D)  IgG 
A)  IgM 
B)  IgA 
C)  IgE 
D)  IgG

Question 19

MATCHING
Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once.
-Associated with immediate-spin in vitro reactions

Accepted Answer

A) IgA 
B) IgM 
C) IgG 
D) IgE 
A) IgA 
B) IgM 
C) IgG 
D) IgE

Which of the following components in the complement cascade mediates the lysis of the target cells?

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Has the highest serum concentration

An antigen that originates from the individual is termed:

What immunoglobulin class is capable of crossing the placenta?

What part of the immunoglobulin molecule distinguishes the isotype?

An antibody identified in the transfusion service appeared to be reacting stronger following the second exposure to an antigen from a transfusion.The most likely explanation of this observation is:

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Has the highest number of antigen binding sites

Select the substance that regulates the activity of other cells by binding to specific receptors.

What portion of the antibody molecule binds to receptors on macrophages and assists in the removal of antibody bound to red cells?

After adding antigen and antibody to a test tube,one large agglutinate was observed.How should this reaction be graded?

Select the term that describes cells or tissue from a genetically different individual within the same species.

Which of the following requires adjustment in order to enhance the reaction of an antibody in vitro?

When testing for the A antigen in a patient,what would you use to perform the test?

Which of the following is responsible for the activation of the classic pathway of complement?

Select the term from the list below that best fits the definitions. -Variable region of an immunoglobulin

In a serologic test,the term prozone is also known as:

Select the region of the antibody molecule responsible for imparting unique antibody specificity.

What immunoglobulin class reacts best at room temperature at immediate-spin?

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Associated with immediate-spin in vitro reactions

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

ABO and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Filters

Exam 2: Immunology: Basic Principles and Applications in the Blood Bank

Which of the following components in the complement cascade mediates the lysis of the target cells?

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Has the highest serum concentration

An antigen that originates from the individual is termed:

What immunoglobulin class is capable of crossing the placenta?

What part of the immunoglobulin molecule distinguishes the isotype?

An antibody identified in the transfusion service appeared to be reacting stronger following the second exposure to an antigen from a transfusion.The most likely explanation of this observation is:

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Has the highest number of antigen binding sites

Select the substance that regulates the activity of other cells by binding to specific receptors.

What portion of the antibody molecule binds to receptors on macrophages and assists in the removal of antibody bound to red cells?

After adding antigen and antibody to a test tube,one large agglutinate was observed.How should this reaction be graded?

Select the term that describes cells or tissue from a genetically different individual within the same species.

Which of the following requires adjustment in order to enhance the reaction of an antibody in vitro?

When testing for the A antigen in a patient,what would you use to perform the test?

Which of the following is responsible for the activation of the classic pathway of complement?

Select the term from the list below that best fits the definitions. -Variable region of an immunoglobulin

In a serologic test,the term prozone is also known as:

Select the region of the antibody molecule responsible for imparting unique antibody specificity.

What immunoglobulin class reacts best at room temperature at immediate-spin?

MATCHING Select the immunoglobulin class from the list below that best fits the characteristic described.Each class can be used more than once. -Associated with immediate-spin in vitro reactions

Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank

Blood Banking Reagents: Overview and Applications

Genetic Principles in Blood Banking

ABO and H Blood Group Systems and Secretor Status

Rh Blood Group System

Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Antibody Detection and Identification

Compatibility Testing

Blood Bank Automation for Transfusion Services

Adverse Complications of Transfusions

Hemolytic Disease of the Fetus and Newborn

Donor Selection and Phlebotomy

Testing of Donor Blood

Blood Component Preparation and Therapy

Transfusion Therapy in Selected Patients

Filters