Question 1

New generation antipsychotic drugs, such as clozapine, do not cause severe motor dysfunction because they

Accepted Answer

A)  bind more tightly to D₂ receptors. 
B)  don't block dopamine activity. 
C)  are less competitive than dopamine in the basal ganglia. 
D)  agonize serotonin more than dopamine. 
A)  bind more tightly to D₂ receptors. 
B)  don't block dopamine activity. 
C)  are less competitive than dopamine in the basal ganglia. 
D)  agonize serotonin more than dopamine. C

Question 2

An experimental procedure where amphetamines are administered to schizophrenic patients to measure dopamine release is called

Accepted Answer

A)  amphetamine sensitization. 
B)  amphetamine challenge. 
C)  receptor challenge. 
D)  amphetamine psychosis. 
A)  amphetamine sensitization. 
B)  amphetamine challenge. 
C)  receptor challenge. 
D)  amphetamine psychosis. B

Question 3

All of the following are negative schizophrenic symptoms EXCEPT

Accepted Answer

A)  muted expression. 
B)  lack of speech. 
C)  avolition. 
D)  catatonic behavior. 
A)  muted expression. 
B)  lack of speech. 
C)  avolition. 
D)  catatonic behavior. D

Question 4

Positive symptoms of schizophrenia are characterized by

Accepted Answer

A)  their likeliness to be eliminated with drug treatment. 
B)  behavior that is not typically disruptive. 
C)  excessive or distorted behavior. 
D)  a lack of appropriate behaviors. 
A)  their likeliness to be eliminated with drug treatment. 
B)  behavior that is not typically disruptive. 
C)  excessive or distorted behavior. 
D)  a lack of appropriate behaviors.

Question 5

The most predictive feature of an antipsychotic's propensity to cause extrapyramidal symptoms is

Accepted Answer

A)  how tightly it competes for D₂ receptors in the basal ganglia. 
B)  its affinity for serotonergic receptors. 
C)  its affinity for cholinergic receptors. 
D)  its antagonism of 5-HTᴀ₂ receptors. 
A)  how tightly it competes for D₂ receptors in the basal ganglia. 
B)  its affinity for serotonergic receptors. 
C)  its affinity for cholinergic receptors. 
D)  its antagonism of 5-HTᴀ₂ receptors.

Question 6

Occasionally, the speech of a schizophrenic can be so disjointed that it is referred to as

Accepted Answer

A)  jumbled speech. 
B)  word salad. 
C)  speech derailment. 
D)  None of the above is correct 
A)  jumbled speech. 
B)  word salad. 
C)  speech derailment. 
D)  None of the above is correct

Question 7

It is alleged that glutamate dysfunction in the thalamus and hippocampus leads to ________ activity in the cortex and to the development of negative symptoms in later stages of schizophrenia.

Accepted Answer

A)  decreased BDNF 
B)  excessive dopamine 
C)  excitotoxic glutamate 
D)  Both a and c are correct 
A)  decreased BDNF 
B)  excessive dopamine 
C)  excitotoxic glutamate 
D)  Both a and c are correct

Question 8

Long-term treatment with phenothiazines may cause

Accepted Answer

A)  severe memory deficits. 
B)  sexual dysfunction. 
C)  Parkinson's disease. 
D)  tardive dyskinesia. 
A)  severe memory deficits. 
B)  sexual dysfunction. 
C)  Parkinson's disease. 
D)  tardive dyskinesia.

Question 9

Tardive dyskinesia is characterized by

Accepted Answer

A)  facial tics. 
B)  tongue extensions. 
C)  rapid eye blinking. 
D)  All of the above are correct 
A)  facial tics. 
B)  tongue extensions. 
C)  rapid eye blinking. 
D)  All of the above are correct

Question 10

Which of the following statements is TRUE regarding schizophrenia?

Accepted Answer

A)  Schizophrenia typically emerges in late childhood. 
B)  The most distinctive feature of schizophrenia is the presence of disorganized speech and behavior. 
C)  Children of schizophrenic parents have a tenfold risk of developing the disease. 
D)  The lifetime prevalence of schizophrenia worldwide is about 5 percent. 
A)  Schizophrenia typically emerges in late childhood. 
B)  The most distinctive feature of schizophrenia is the presence of disorganized speech and behavior. 
C)  Children of schizophrenic parents have a tenfold risk of developing the disease. 
D)  The lifetime prevalence of schizophrenia worldwide is about 5 percent.

Question 11

It is estimated that the phenothiazine dose required to obtain a therapeutic effect must be sufficient to occupy between ________ and ________ percent of D₂ receptors.

Accepted Answer

A)  25; 35 
B)  35; 45 
C)  50; 60 
D)  70; 80 
A)  25; 35 
B)  35; 45 
C)  50; 60 
D)  70; 80

Question 12

An animal model of psychosis that has proven useful in investigating the effectiveness of antipsychotic drugs is

Accepted Answer

A)  prepulse inhibition. 
B)  forced swimming. 
C)  the elevated maze. 
D)  None of the above is correct 
A)  prepulse inhibition. 
B)  forced swimming. 
C)  the elevated maze. 
D)  None of the above is correct

Question 13

Schizophrenic patients have depressed numbers of NMDA receptors in the ________ and the ________.

Accepted Answer

A)  thalamus; frontal cortex 
B)  hippocampus; thalamus 
C)  medulla; hippocampus 
D)  frontal cortex; medulla 
A)  thalamus; frontal cortex 
B)  hippocampus; thalamus 
C)  medulla; hippocampus 
D)  frontal cortex; medulla

Question 14

________ was the first antipsychotic that appeared to improve the symptoms of schizophrenia without causing severe Parkinsonian-like effects.

Accepted Answer

A)  Haloperidol 
B)  Chlorpromazine 
C)  Risperidone 
D)  Clozapine 
A)  Haloperidol 
B)  Chlorpromazine 
C)  Risperidone 
D)  Clozapine

Question 15

The dopamine hypothesis of schizophrenia proposes that schizophrenia is a consequence of

Accepted Answer

A)  abnormally low dopamine activity. 
B)  excessive dopamine receptors in certain brain regions. 
C)  excessive dopamine activity in the striatum and mesolimbic pathways. 
D)  excessive dopamine activity in the prefrontal cortex. 
A)  abnormally low dopamine activity. 
B)  excessive dopamine receptors in certain brain regions. 
C)  excessive dopamine activity in the striatum and mesolimbic pathways. 
D)  excessive dopamine activity in the prefrontal cortex.

Question 16

All of the following were treatments used for schizophrenia prior to the 1950s EXCEPT

Accepted Answer

A)  insulin shock. 
B)  frontal lobotomy. 
C)  physical restraint. 
D)  phenothiazines. 
A)  insulin shock. 
B)  frontal lobotomy. 
C)  physical restraint. 
D)  phenothiazines.

Question 17

About ________ to ________ percent of schizophrenic patients eventually respond to medication.

Accepted Answer

A)  10; 15 
B)  30; 45 
C)  75; 85 
D)  80; 100 
A)  10; 15 
B)  30; 45 
C)  75; 85 
D)  80; 100

Question 18

According to the dopamine hypothesis, the negative symptoms of schizophrenia result from ________ activity in ________.

Accepted Answer

A)  hyperdopaminergic; the prefrontal cortex 
B)  hypodopaminergic; the mesolimbic system. 
C)  hypodopaminergic; mesocortical pathways to the prefrontal cortex 
D)  None of the above is correct 
A)  hyperdopaminergic; the prefrontal cortex 
B)  hypodopaminergic; the mesolimbic system. 
C)  hypodopaminergic; mesocortical pathways to the prefrontal cortex 
D)  None of the above is correct

Question 19

Extrapyramidal symptoms are debilitating motor disruptions that are

Accepted Answer

A)  caused in the pyramidal tracks descending from the medulla. 
B)  not caused in the motor system itself. 
C)  caused by damage to neurons above the pyramidal tracks. 
D)  None of the above is correct 
A)  caused in the pyramidal tracks descending from the medulla. 
B)  not caused in the motor system itself. 
C)  caused by damage to neurons above the pyramidal tracks. 
D)  None of the above is correct

Question 20

Negative symptoms of schizophrenia are characterized by

Accepted Answer

A)  their unlikeliness to be eliminated with drug treatment. 
B)  behavior that is not typically disruptive. 
C)  excessive or distorted behavior. 
D)  absent or deficient behavior. 
A)  their unlikeliness to be eliminated with drug treatment. 
B)  behavior that is not typically disruptive. 
C)  excessive or distorted behavior. 
D)  absent or deficient behavior.

New generation antipsychotic drugs, such as clozapine, do not cause severe motor dysfunction because they

An experimental procedure where amphetamines are administered to schizophrenic patients to measure dopamine release is called

All of the following are negative schizophrenic symptoms EXCEPT

Positive symptoms of schizophrenia are characterized by

The most predictive feature of an antipsychotic's propensity to cause extrapyramidal symptoms is

Occasionally, the speech of a schizophrenic can be so disjointed that it is referred to as

It is alleged that glutamate dysfunction in the thalamus and hippocampus leads to ________ activity in the cortex and to the development of negative symptoms in later stages of schizophrenia.

Long-term treatment with phenothiazines may cause

Tardive dyskinesia is characterized by

Which of the following statements is TRUE regarding schizophrenia?

It is estimated that the phenothiazine dose required to obtain a therapeutic effect must be sufficient to occupy between and percent of D₂ receptors.

An animal model of psychosis that has proven useful in investigating the effectiveness of antipsychotic drugs is

Schizophrenic patients have depressed numbers of NMDA receptors in the and the .

________ was the first antipsychotic that appeared to improve the symptoms of schizophrenia without causing severe Parkinsonian-like effects.

The dopamine hypothesis of schizophrenia proposes that schizophrenia is a consequence of

All of the following were treatments used for schizophrenia prior to the 1950s EXCEPT

About to percent of schizophrenic patients eventually respond to medication.

According to the dopamine hypothesis, the negative symptoms of schizophrenia result from activity in .

Extrapyramidal symptoms are debilitating motor disruptions that are

Negative symptoms of schizophrenia are characterized by

Organization and Function of the Nervous System

Psychopharmacology: Pharmacokinetics and Pharmacodynamics

Mood Disorders: Major Depression and Bipolar Disorders

Anxiety and Stress Related Disorders: Panic, Generalized Anxiety, Obsessive Compulsive Disorder, and Posttraumatic Stress Disorder

Attention and Developmental Disorders: Attention-Deficithyperactivity Disorder and Autism Spectrum Disorder

The Pharmacology of Opiates and Analgesia

Substance Abuse and the Neurobiology of Addiction, 2nd Edition

The Pharmacology of Scheduled Psychoactive Drugs: Psychostimulants, Psychedelics, and Marijuana

The Pharmacology of Non Scheduled Psychoactive Drugs: Alcohol, Nicotine, and Caffeine

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Exam 5: Psychotic Disorders: Schizophrenia

New generation antipsychotic drugs, such as clozapine, do not cause severe motor dysfunction because they

An experimental procedure where amphetamines are administered to schizophrenic patients to measure dopamine release is called

All of the following are negative schizophrenic symptoms EXCEPT

Positive symptoms of schizophrenia are characterized by

The most predictive feature of an antipsychotic's propensity to cause extrapyramidal symptoms is

Occasionally, the speech of a schizophrenic can be so disjointed that it is referred to as

It is alleged that glutamate dysfunction in the thalamus and hippocampus leads to ________ activity in the cortex and to the development of negative symptoms in later stages of schizophrenia.

Long-term treatment with phenothiazines may cause

Tardive dyskinesia is characterized by

Which of the following statements is TRUE regarding schizophrenia?

It is estimated that the phenothiazine dose required to obtain a therapeutic effect must be sufficient to occupy between ________ and ________ percent of D₂ receptors.

An animal model of psychosis that has proven useful in investigating the effectiveness of antipsychotic drugs is

Schizophrenic patients have depressed numbers of NMDA receptors in the ________ and the ________.

________ was the first antipsychotic that appeared to improve the symptoms of schizophrenia without causing severe Parkinsonian-like effects.

The dopamine hypothesis of schizophrenia proposes that schizophrenia is a consequence of

All of the following were treatments used for schizophrenia prior to the 1950s EXCEPT

About ________ to ________ percent of schizophrenic patients eventually respond to medication.

According to the dopamine hypothesis, the negative symptoms of schizophrenia result from ________ activity in ________.

Extrapyramidal symptoms are debilitating motor disruptions that are

Negative symptoms of schizophrenia are characterized by

Organization and Function of the Nervous System

Psychopharmacology: Pharmacokinetics and Pharmacodynamics

Mood Disorders: Major Depression and Bipolar Disorders

Anxiety and Stress Related Disorders: Panic, Generalized Anxiety, Obsessive Compulsive Disorder, and Posttraumatic Stress Disorder

Attention and Developmental Disorders: Attention-Deficithyperactivity Disorder and Autism Spectrum Disorder

The Pharmacology of Opiates and Analgesia

Substance Abuse and the Neurobiology of Addiction, 2nd Edition

The Pharmacology of Scheduled Psychoactive Drugs: Psychostimulants, Psychedelics, and Marijuana

The Pharmacology of Non Scheduled Psychoactive Drugs: Alcohol, Nicotine, and Caffeine

Filters

It is estimated that the phenothiazine dose required to obtain a therapeutic effect must be sufficient to occupy between and percent of D₂ receptors.

Schizophrenic patients have depressed numbers of NMDA receptors in the and the .

About to percent of schizophrenic patients eventually respond to medication.

According to the dopamine hypothesis, the negative symptoms of schizophrenia result from activity in .