Exam 8: Sleep and Biological Rhythms

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Secretion of orexin within the _______ produces ______.

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Compare and contrast the neural systems that control slow-wave and REM sleep with regard to anatomy and the relevant transmitters involved in each.

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Slow-wave sleep is produced by activity of neurons within the ventrolateral preoptic area (vlPOA),which act by inhibition of neural systems that promote wakefulness (e.g.,NE within the locus coeruleus,histamine in the tuberomammillary nucleus,and serotonin within the raphe nuclei) to initiate sleep.When the sleep-waking flip-flop is in the awake state,sleep is prevented.In the sleep state,slow-wave sleep shifts to REM sleep via another flip-flop mechanism in which cells within the sublaterodorsal nucleus act as "REM-ON" cells while cells within the ventrolateral PAG act as a "REM-OFF" region.When the REM-ON cells are active,motor neurons of the spinal cord are inhibited,whereas tectal neurons generate rapid eye movements.

An electro-oculogram measures

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Antidepressant drugs are also effective against disorders of REM sleep.

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Activation of adenosine receptors may increase sleep by

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Give two reasons why sleeping medications may not be the right treatment for insomnia.

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Sleep disorders that occur during or involve REM sleep include

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The high level of delta waves in normally active brain areas suggests that the primary function of stage 4 of slow-wave sleep is to

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Microdialysis studies indicate that cortical beta wave activity is related to its levels of ________ within the ________.

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Describe the laboratory methods used to study sleep.

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The appearance of rapid eye movements in the sleep record is an indicator of

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Activation of lateral preoptic neurons may mediate the genital arousal noted during REM sleep.

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Which of the following is a rhythm that tends to occur over a 90 minute period?

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A genetic mutation of the hypocretin gene in mice results in

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Insomnia is defined

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Neural activity in the suprachiasmatic nuclei in rats is

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Contrast the effects of acetylcholine and serotonin on cortical arousal.

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Sleep stages 3 and 4 are also called

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Prolonged sleep deprivation results in

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Describe the symptoms of narcolepsy.

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