Exam 16:What Happens When the Brain Misbehaves?

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What are the symptoms and causes of phenylketonuria?

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Phenylketonuria (PKU) is a genetic disorder that causes a buildup of phenylalanine in the body. This can lead to a variety of symptoms and health issues.

Symptoms of PKU can include developmental delays, intellectual disability, seizures, behavioral problems, and a musty odor in the breath, skin, or urine. If left untreated, PKU can also lead to severe intellectual disability.

The main cause of PKU is a genetic mutation that affects the enzyme responsible for breaking down phenylalanine. This mutation prevents the body from properly processing phenylalanine, leading to its accumulation in the body.

PKU is usually diagnosed through newborn screening, which allows for early intervention and treatment. Treatment for PKU typically involves a strict low-phenylalanine diet, which can help prevent the buildup of phenylalanine and reduce the risk of symptoms and complications.

It's important for individuals with PKU to work closely with healthcare professionals, including dietitians and genetic counselors, to manage their condition and ensure they receive the necessary support and care.

What is chronic traumatic encephalopathy (CTE)? What neural changes accompany it?

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Chronic traumatic encephalopathy (CTE) is a degenerative brain disease that is caused by repeated head injuries, such as concussions. It is commonly found in athletes who participate in contact sports, as well as military veterans and others who have experienced repetitive head trauma.

The neural changes that accompany CTE include the accumulation of an abnormal protein called tau in the brain. This protein forms clumps that spread throughout the brain, causing damage to brain cells and disrupting normal brain function. This can lead to a range of symptoms, including memory loss, confusion, impaired judgment, aggression, depression, and eventually, progressive dementia.

In addition to tau protein accumulation, CTE is also associated with widespread neuroinflammation, which can further contribute to the degeneration of brain tissue. These neural changes can have a profound impact on an individual's cognitive and emotional functioning, and can significantly impair their quality of life. As our understanding of CTE continues to evolve, researchers are working to develop better diagnostic tools and potential treatments for this devastating condition.

What treatments are available to reduce epileptic seizures?

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There are several treatments available to reduce epileptic seizures, and the appropriate approach depends on the individual's specific type of epilepsy, the frequency and severity of seizures, their overall health, and other factors. Here are some of the most common treatments:

1. **Medication**: Antiepileptic drugs (AEDs) are the most common treatment for epilepsy. They work by altering the electrical activity in the brain to prevent seizures. There are many different AEDs, and sometimes a combination of drugs is used. It may take time to find the most effective medication and dosage with the fewest side effects.

2. **Surgery**: When seizures are not controlled by medication, surgery may be an option. This typically involves removing the area of the brain where seizures originate. Surgery is more likely to be considered if the seizure focus is located in an area of the brain that doesn't control vital functions like speech, language, or motor function.

3. **Vagus Nerve Stimulation (VNS)**: This involves implanting a device under the skin of the chest that sends regular, mild pulses of electrical energy to the brain via the vagus nerve. VNS can help reduce the number and intensity of seizures.

4. **Responsive Neurostimulation (RNS)**: This is a newer treatment that involves placing a neurostimulator within the skull. The device monitors brain activity and delivers electrical stimulation when it detects patterns that may lead to a seizure.

5. **Dietary Therapy**: Certain diets, such as the ketogenic diet or the modified Atkins diet, have been shown to help control seizures in some people, particularly children. These diets are high in fats and low in carbohydrates, which can change the way the body uses energy and may help to reduce seizures.

6. **Lifestyle Changes**: Adequate sleep, stress management, and avoiding seizure triggers can help reduce the frequency of seizures for some individuals.

7. **Cannabidiol (CBD)**: The FDA has approved a purified form of CBD, a compound found in cannabis, for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome.

8. **Deep Brain Stimulation (DBS)**: Similar to VNS, DBS involves implanting electrodes in specific areas of the brain. These electrodes are connected to a pulse generator that sends electrical impulses to brain areas involved in seizure activity.

9. **Alternative Therapies**: Some people may explore alternative therapies such as acupuncture, biofeedback, or herbal supplements, although the evidence supporting these treatments is less robust.

It's important to note that not all treatments are suitable for every individual with epilepsy, and it may take time to find the most effective approach. Treatment plans should always be developed in consultation with a healthcare professional, typically a neurologist or an epileptologist, who specializes in treating epilepsy. Regular monitoring and follow-up are essential to manage the condition effectively and to adjust treatment as necessary.

What is the MOST common form of brain damage in people under 40?

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List and describe four major types of behavioral therapies for behavioral disorders outlined in your text.

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What neurotransmitters appear to be involved in depression?

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What are prions? What neurological diseases may be caused by prions?

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What neural changes do Parkinson and Alzheimer disease have in common?

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Differentiate between coup and contrecoup effects during a traumatic brain injury.Give an example.

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What processes following an ischemic stroke result in further brain damage?

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What is magnetic resonance spectroscopy? How is it used to diagnose traumatic brain injury?

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What can happen if a person has multiple concussions throughout life?

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What neurotransmitter system(s)are involved in anxiety? What types of drugs are used to treat anxiety disorders?

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What is electroconvulsive therapy? Why is it used? How does it affect the brain?

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What is the hypothalamic-pituitary-adrenal axis? What role does it play in depression?

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What kinds of neurosurgeries have been used in treating Parkinson disease?

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What are the proposed causes of multiple sclerosis?

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Give examples of positive and negative symptoms of Parkinson disease.

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Describe and explain at least four of the major challenges faced by researchers who want to study the disordered brain.

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List the six diagnostic symptoms of schizophrenia.

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