Question 1

A 16-year-old girl develops shortness of breath,runny nose,wheezing,and chest tightening with no fever.A spirometry test is performed and reveals that her FEV1 is reduced and the ratio of FEV1 to FVC is abnormal.Her FEV1 improves by 15% after bronchodilator use.A chest radiograph is also obtained.The family mentions that they purchased a cat several weeks ago.You suspect allergic asthma. Increased levels of what type of serum antibody would you like to see to confirm your diagnosis?

Accepted Answer

A) Immunoglobulin A (Ig
A)  
B) IgG 
C) IgM 
D) IgE 
E) IgD D

Question 2

A 56-year-old woman has worked in a photography shop developing film for the past 20 years.She has a long history of shortness of breath and chronic cough,which have progressively become worse.Her forced expiratory volume in 1 second (FEV1)and forced vital capacity (FVC)values were reduced,but the FEV1/FVC ratio was within the normal range.Her diffusion capacity,as measured with diffusion of carbon monoxide in the lungs (DLco),was low,at 15 mL/minute/mm Hg.Bronchoalveolar lavage and tissue biopsy were performed.The lavage sample revealed high numbers of abnormal-appearing macrophages and high numbers of dead macrophages. What type of lung disease do you suspect?

Accepted Answer

A) Restrictive disease 
B) Obstructive disease 
C) Infectious disease 
D) Lung cancer 
E) Genetically inherited disease A

Question 3

The four cell types that contribute to the quantity and composition of mucus include:

Accepted Answer

A) Type II epithelial cells,mucous and serous cells within the submucosal tracheobronchial glands,and Clara cells 
B) Type II epithelial cells,mucous cells within the submucosal tracheobronchial glands,goblet cells,and Clara cells 
C) Type II epithelial cells,mucous and serous cells within the submucosal tracheobronchial glands,and goblet cells 
D) Goblet cells,mucous and serous cells within the submucosal tracheobronchial glands,and Clara cells D

Question 4

A 56-year-old woman has worked in a photography shop developing film for the past 20 years.She has a long history of shortness of breath and chronic cough,which have progressively become worse.Her FEV1 and FVC values were reduced,but the FEV1/FVC ratio was within the normal range.Her diffusion capacity,as measured with DLco,was low,at 15 mL/minute/mm Hg.Bronchoalveolar lavage and tissue biopsy were performed.The lavage sample revealed high numbers of abnormal-appearing macrophages and high numbers of dead macrophages. What type of pathologic process would you expect to find?

Accepted Answer

A) Peribronchial inflammation with eosinophils 
B) Granuloma-like lesion in the terminal bronchioles with interstitial fibrosis and large foamy macrophages 
C) Interstitial edema fluid accumulation with neutrophil infiltrate 
D) Emphysematous lesion with large alveoli and minimum interstitial fibrosis

Question 5

A 56-year-old woman has worked in a photography shop developing film for the past 20 years.She has a long history of shortness of breath and chronic cough,which have progressively become worse.Her FEV1 and FVC values were reduced,but the FEV1/FVC ratio was within the normal range.Her diffusion capacity,as measured by DLco,was low,at 15 mL/min/mm Hg.Bronchoalveolar lavage and tissue biopsy were performed.The lavage sample revealed high numbers of abnormal-appearing macrophages and high numbers of dead macrophages. What is the specific diagnosis?

Accepted Answer

A) Allergic airway disease 
B) Chronic bronchitis 
C) Silicosis 
D) Pneumoconiosis 
E) Tuberculosis

Question 6

A 50-year-old male coal miner has a long history of lung disease.Where in the lung would you expect to find the greatest deposition of inhaled coal dust?

Accepted Answer

A) Terminal bronchioles 
B) Bronchi 
C) Nonrespiratory bronchioles 
D) Alveolus 
E) Trachea

Exam 26: Non-Physiologic Functions of the Lung: Host Defense and Metabolism

The four cell types that contribute to the quantity and composition of mucus include:

A 50-year-old male coal miner has a long history of lung disease.Where in the lung would you expect to find the greatest deposition of inhaled coal dust?