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Essay

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Once we had a human genetic map, a general method, ____1____ ____2____, could be applied to identifying genes underling single gene disorders. In order to carry this through, there was first the need to identify families with multiple affected individuals and to obtain samples of ____3____ ____4____ from both affected and unaffected family members. The individual samples could then be tested by assaying each of several hundred DNA ____5_____ . The DNA ____5____ were selected because they were known to be ____6____ and because they were each known to map to a ____7____ subchromosomal location. The object was to identify ____5____ that must map close to the disease gene because alleles from these markers tended to ____8____ with disease through generations in families.