Why Are Antibodies to High-Frequency Antigens, Such as Cellano (K)

Multiple Choice

Why are antibodies to high-frequency antigens, such as cellano (k) , rarely seen in patient samples?

A) Most persons are not antigenically stimulated to produce the antibody, because their red blood cells are negative for the antigen.
B) Most persons are not antigenically stimulated to produce the antibody, because their red blood cells are positive for the antigen.
C) Anti-k has low avidity.
D) Most reagent cells are heterozygous for cellano.