The Results of Two Sets of Chromatin Immunoprecipitation Experiments on Two

Multiple Choice

The results of two sets of chromatin immunoprecipitation experiments on two cell types (1 and 2) are shown in the following simplified graphs for the same genomic region containing the first two exons of a gene. Antibodies against a transcription regulatory protein (X) or against a subunit of RNA polymerase II were used in the ChIP-seq experiments, as indicated. Do you think the protein is a transcriptional activator or repressor? The results from a parallel RNA-seq experiment are provided in the third graph. Which profile (a or b) in the graph would you expect to correspond to cell type 1?

A) Activator; profile a
B) Repressor; profile a
C) Activator; profile b
D) Repressor; profile b