The Strength of Integrin-Dependent Binding of T Cells to Antigen-Presenting

Multiple Choice

The strength of integrin-dependent binding of T cells to antigen-presenting cells (APCs) may be rapidly increased by which one of the following mechanisms?

A) Integrin clustering and increased integrin affinity are induced by chemokines and antigen recognition.
B) Integrins stored in cytoplasmic organelles are mobilized to the T cell surface in response to TCR-mediated signals.
C) Integrin gene transcription is enhanced by chemokine-generated signals.
D) The affinity of integrin ligands on APCs is increased in response to chemokines.
E) Integrin ligands stored in cytoplasmic granules in the APCs are mobilized to the cell surface in response to CD40-CD40 ligand interaction.