Question 1

_______ produced by the weak stimulus depends only on post-translation modifications and rearrangements of existing protein.

Accepted Answer

S-LTP

Question 2

What is the major assumption in the soma-to-nucleus signaling model?

Accepted Answer

Action potentials produced when a cell depolarizes open voltage-dependent calcium channels near the soma that signal the nucleus.

Question 3

Why does separating the dendrites from the soma provide evidence for local protein synthesis?

Accepted Answer

If the dendrites are separated from the soma, there is no way synaptic activity can signal the nucleus and no way for new plasticity products generated in the nucleus to reach the stimulated synapse.

Question 4

The idea that synaptic activity leads to the transcription of new plasticity product needed to build long-lasting LTP is called the _______. (Select all that apply.)

Accepted Answer

A)   translation hypothesis
B)   genomic signaling hypotheses
C)   post-translation modification hypothesis
D)   local protein synthesis hypothesis
E)   soma-to-nucleus hypothesis

Question 5

A strong stimulus initiates what two rounds of protein synthesis?

Accepted Answer

The answer of A strong stimulus initiates what two rounds...

Question 6

Pretreatment with anisomycin, a protein synthesis inhibitor, prevents the strong stimulus from producing _______.

Accepted Answer

The answer of Pretreatment with anisomycin, a protein synthesis inhibitor,...

Question 7

Why has anisomycin been used to study LTP?

Accepted Answer

The answer of Why has anisomycin been used to study...

Question 8

According to the de novo protein synthesis (DNPS) hypothesis, long-lasting memories require that the learning experience generate new proteins.

Accepted Answer

A) True 
 B)False

Question 9

In the soma-to-nucleus cascade, repetitive action potentials are assumed to open voltage-dependent calcium channels.

Accepted Answer

A) True 
 B)False

Question 10

Why is emetine important?

Accepted Answer

The answer of Why is emetine important?...

Question 11

What are plasticity products (PPs)?

Accepted Answer

The answer of What are plasticity products (PPs)?...

Question 12

Which can be found in the dendritic region? (Select all that apply.)

Accepted Answer

A)   Endoplasmic reticulum and Golgi elements
B)   Transcription factors, ribosomal assemblies, and mRNAs
C)   Ribosomal assemblies and mRNAs
D)   Golgi elements
E)   None of the above

Question 13

What two major findings illustrate the important role local protein synthesis plays in L-LTP?

Accepted Answer

The answer of What two major findings illustrate the important...

Question 14

Describe the de novo protein synthesis hypothesis.

Accepted Answer

The answer of Describe the de novo protein synthesis hypothesis....

Question 15

Which statement(s) about IP3 is/are true? (Select all that apply.)

Accepted Answer

A)   IP3 requires calcium to enter the cell.
B)   IP3 is regulated by NMDA receptors.
C)   IP3 is regulated by mGluRs.
D)   IP3 binds to RYRs.
E)   None of the above

Question 16

Genomic signaling refers to processes initiated by synaptic events that lead to the transcription of new mRNA.

Accepted Answer

A) True 
 B)False

Question 17

What is a major feature of the genomic signaling hypothesis?

Accepted Answer

The answer of What is a major feature of the...

Question 18

Which observation(s) support(s) the idea that the fundamental consolidating event is the construction of an enlarged stable spine? (Select all that apply.)

Accepted Answer

A)   Inhibiting NMDA receptors prevent LTP induction.
B)   Preventing actin polymerization prevents LTP from enduring.
C)   Preventing cofilin phosphorylation prevents LTP from enduring.
D)   Inhibiting actin polymerization prevents the generation of LTP.
E)   None of the above

Question 19

Calcium-induced calcium release refers to extracellular calcium entering the cell.

Accepted Answer

A) True 
 B)False

Question 20

Calcium-induced calcium release occurs when calcium entering via NMDA receptors binds to RyRs on the endoplasmic reticulum.

Accepted Answer

A) True 
 B)False

Exam 5: Consolidating Ltp: Translation and Transcription

_______ produced by the weak stimulus depends only on post-translation modifications and rearrangements of existing protein.

What is the major assumption in the soma-to-nucleus signaling model?

Why does separating the dendrites from the soma provide evidence for local protein synthesis?

The idea that synaptic activity leads to the transcription of new plasticity product needed to build long-lasting LTP is called the _______. (Select all that apply.)

A strong stimulus initiates what two rounds of protein synthesis?

Pretreatment with anisomycin, a protein synthesis inhibitor, prevents the strong stimulus from producing _______.

Why has anisomycin been used to study LTP?

According to the de novo protein synthesis (DNPS) hypothesis, long-lasting memories require that the learning experience generate new proteins.

In the soma-to-nucleus cascade, repetitive action potentials are assumed to open voltage-dependent calcium channels.

Why is emetine important?

What are plasticity products (PPs)?

Which can be found in the dendritic region? (Select all that apply.)

What two major findings illustrate the important role local protein synthesis plays in L-LTP?

Describe the de novo protein synthesis hypothesis.

Which statement(s) about IP3 is/are true? (Select all that apply.)

Genomic signaling refers to processes initiated by synaptic events that lead to the transcription of new mRNA.

What is a major feature of the genomic signaling hypothesis?

Which observation(s) support(s) the idea that the fundamental consolidating event is the construction of an enlarged stable spine? (Select all that apply.)

Calcium-induced calcium release refers to extracellular calcium entering the cell.

Calcium-induced calcium release occurs when calcium entering via NMDA receptors binds to RyRs on the endoplasmic reticulum.