Transgenic Mouse Lines Have Been Very Useful for the Study

Multiple Choice

Transgenic mouse lines have been very useful for the study of mechanisms of self-tolerance.In one such line,transgenes were introduced encoding a T cell receptor (TCR) specific for the H-Y antigen,which is a protein expressed by many cell types only in male mice.When these transgenic mice were analyzed,researchers found that T cells expressing the H-Y-specific TCR developed normally in female mice but not in male mice.This finding illustrates which of the following mechanism of self tolerance?

A) Peripheral anergy
B) Central (thymic) deletion
C) Clonal ignorance
D) Regulatory T cell-mediated suppression
E) Peripheral deletion