Which of the Following Statements About Induction or Maintenance of T

Multiple Choice

Which of the following statements about induction or maintenance of T cell tolerance is NOT true?

A) Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self antigens.
B) Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1- or B7-2-mediated costimulation.
C) Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
D) Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
E) Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.