Many Tumors Are Found to Overexpress Bcl-2,which Favors Survival of the Transformed

Multiple Choice

Many tumors are found to overexpress bcl-2,which favors survival of the transformed cells.Which of the following best describes the function of bcl-2?

A) Direct inhibition of caspase-8
B) Direct inhibition of caspase-9
C) Up-regulates expression of DNA repair enzymes
D) Reduces the leakiness of the mitochondrial membrane
E) Inhibits the activity of granzymes released from cytotoxic T lymphocytes