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A 7-Month-Old Boy Is Evaluated in the Clinic for Recurrent γ\gamma

Question 13

Multiple Choice

A 7-month-old boy is evaluated in the clinic for recurrent bacterial infections.His tonsils are not visible on physical examination.Serum immunoglobulin A (IgA) and IgG levels are markedly decreased,and serum IgM levels are slightly below normal.Based on this family's history and clinical presentation,a mutation in which of the following genes is most likely to be found in this patient?


A) JAK3 kinase
B) Adenosine deaminase
C) Common cytokine receptor γ\gamma chain
D) RAG2
E) Purine nucleoside phosphorylase

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