Which Will Not Increase the Rate of Conversion of Reactant

Multiple Choice

Which will not increase the rate of conversion of reactant A to product B in the presence of enzyme C?

A) An increase in enzyme concentration
B) An increase in temperature to the optimum for the reaction
C) An increase in substrate concentration
D) The addition of a nonbiological molecule that can catalyze the same reaction
E) The addition of D that can compete with A for binding at the active site of C