Multiple Choice
The AIRE protein is expressed by thymic medullary epithelial cells and is required for tolerance to many self-antigens.Which one of the following statements about how AIRE functions is correct?
A) AIRE is secreted by thymic medullary epithelial cells,and then binds and blocks the T cell receptors on developing T cells.
B) AIRE suppresses MHC expression by thymic medullary epithelial expression
C) AIRE is secreted by thymic medullary epithelial cells binds to soluble self antigens.
D) AIRE is required for thymic medullary epithelial expression of peripheral tissue antigens,which are then presented to immature T cells.
E) AIRE stimulates expression of immunosuppressive cytokines by thymic medullary epithelial cells.
Correct Answer:
Verified
Correct Answer:
Verified
Q3: Immunologic tolerance is defined as:<br>A)The removal of
Q4: Which of the following statements about induction
Q5: For each feature of self-tolerance described in
Q6: For each feature of self-tolerance described in
Q7: For each feature of self-tolerance described in
Q9: For each feature of self-tolerance described in
Q10: CTLA-4,expressed by regulatory T cells and activated
Q11: For each feature of self-tolerance described in
Q12: For each feature of self-tolerance described in
Q13: Failure of self-tolerance is the cause of