Inflammatory Bowel Disease (Colitis) Is a CD4 T-Cell Mediated Disease $\gamma$

Multiple Choice

Inflammatory bowel disease (colitis) is a CD4 T-cell mediated disease that can be transferred to naive mice by administration of effector CD4 T cells that home to the gastrointestinal tract and induce inflammation. Simultaneous administration of neutralizing antibodies to IL-12p40 can prevent the disease, as can neutralizing antibodies to IL-23p19. Disease symptoms can be exacerbated by administration of IL-23, but not of IL-12. These data strongly suggest that:

A) Both T_H1 and T_H17 effector cells contribute to disease.
B) T_H1 cells producing INF- $\gamma$ are the major causes of disease.
C) IL-12p35 is a critical component of disease induction.
D) The inducible IL-12R $\beta$ subunit is essential for disease induction.
E) Neutralizing antibodies to IL-17 would prevent disease.