Allergic Airway Inflammation Can Be Induced in Mice by Immunizing

Multiple Choice

Allergic airway inflammation can be induced in mice by immunizing them with an allergen that produces a T_H2 effector response, and then challenging the immunized mice with an inhaled form of that allergen. In this disease model, the T_H2 effector cells present in the lung respond to the inhaled allergen challenge by producing type 2 cytokines that recruit eosinophils and induce airway inflammation. In addition, a component of this T_H2 response is antigen-independent, as shown by the effects of administering a neutralizing antibody along with the allergen challenge. This neutralizing antibody (anti-'X' IgG) has the effects shown in Figure Q14) . antibody was shown to inhibit the response of the T_H2 cells, and therefore is likely to be:

A) A neutralizing antibody to IL-12
B) A neutralizing antibody to IL-4
C) A neutralizing antibody to TSLP
D) A neutralizing antibody to STAT4
E) A neutralizing antibody to IL-13