At Early Timepoints Following an Infection, Examination of Lymph Node $\gamma$

Multiple Choice

At early timepoints following an infection, examination of lymph node CD4 T cells responding to the pathogen would show a heterogeneous population of cells representing several different effector lineages. Likewise, the cytokines produced by these cells would include IFN $\gamma$ , IL-4, and possibly others. However, approximately one week later at the peak of the T cell response, the pathogen-specific CD4 T cell population would be largely homogeneous in their production of a single effector subset cytokine profile. This change comes about due to:

A) Death of the CD4 T cells making the non-protective cytokines
B) Increased proliferation of CD4 T cells making protective cytokines
C) Enhanced differentiation of newly activated CD4 T cells into one effector subset
D) Inhibition of antigen-presenting cells by CD4 T cell-derived cytokines
E) Impaired proliferation of effector CD4 T cells by IFN $\gamma$