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The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes α\alpha

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The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR α\alpha locus are compared with those from TCR β\beta -deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots.
The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR \alpha locus are compared with those from TCR \beta -deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. -What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCR \alpha <sup>-/-</sup> to TCR \beta <sup>-/-</sup> thymocytes?

-What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCR α\alpha -/- to TCR β\beta -/- thymocytes?

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