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α\alpha β\beta TCRs Generally Have a Binding Preference for Either Peptide:MHC Class

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α\alpha : β\beta TCRs generally have a binding preference for either peptide:MHC class I or peptide:MHC class II complexes. However, on occasion, one α\alpha : β\beta TCR might actually be able to recognize either class of peptide:MHC complexes. When such an α\alpha : β\beta TCR is expressed on a CD4 T cell, it will only activate its T cell after binding to peptide:MHC class II complexes. Why is this the case?

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The co-receptor (CD4 or CD8) expressed o...

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