Hepatitis C Is a Virus That Infects Hepatocytes, Which Are $\alpha$

Multiple Choice

Hepatitis C is a virus that infects hepatocytes, which are non-immune cells of the liver. Currently, patients with chronic Hepatitis C infections are treated with repeated administration of type I interferon, predominantly interferon $\alpha$ . One aspect of this treatment that might aid the patient's immune system in clearing this virus infection is:

A) Up-regulation of MHC class I expression levels on hepatocytes
B) Activation of macrophages to produce noxious compounds that might kill the virus
C) Induction of an inflammatory response to promote neutrophil trafficking to the liver
D) Production of TNF- $\alpha$ in response to type I interferon leading to vasodilation in the liver
E) Induction of IL-1 and IL-6 leading to the acute phase response