Question 1

Thrombin time is prolonged with a patient who has:

Accepted Answer

A)  Increased levels of fibrin degradation products 
B)  Increased levels of fibrinogen 
C)  Factor deficiencies 
D)  Presence of lupus anticoagulants 
A)  Increased levels of fibrin degradation products 
B)  Increased levels of fibrinogen 
C)  Factor deficiencies 
D)  Presence of lupus anticoagulants A

Question 2

Which of the following is the most appropriate reflex test based on the following laboratory data? PT: normal
APTT: prolonged
Factor VIII: C assay: <1%

Accepted Answer

A)  DRVVT 
B)  Bethesda titer 
C)  Factor IX assay 
D)  Mixing studies 
A)  DRVVT 
B)  Bethesda titer 
C)  Factor IX assay 
D)  Mixing studies B

Question 3

An analyzer is measuring a clot forming by the interaction of a stationary probe with a moving probe in a continuous motion. Suddenly the moving probe stops, and a clot is seen. Name the analyzer.

Accepted Answer

A)  Diagnostica Stago 
B)  MDA 180 
C)  Trinity Biotech AMAX Destiny Plus 
D)  BBL Fibrometer 
A)  Diagnostica Stago 
B)  MDA 180 
C)  Trinity Biotech AMAX Destiny Plus 
D)  BBL Fibrometer D

Question 4

Which of the following is needed to perform an activated partial thromboplastin time?

Accepted Answer

A)  Potassium chloride and partial thromboplastin reagent 
B)  Partial thromboplastin reagent and calcium chloride 
C)  Thromboplastin and potassium chloride 
D)  Thromboplastin and calcium chloride 
A)  Potassium chloride and partial thromboplastin reagent 
B)  Partial thromboplastin reagent and calcium chloride 
C)  Thromboplastin and potassium chloride 
D)  Thromboplastin and calcium chloride

Question 5

POC coagulation testing is beneficial in all of the following situations except:

Accepted Answer

A)  Rapid therapeutic decision making during liver transplant surgery 
B)  Out-patient warfarin monitoring on stabilized patients 
C)  Confirmation testing for VWD following a prolonged APTT result 
D)  Rapid screening of platelet function for patients on aspirin therapy 
A)  Rapid therapeutic decision making during liver transplant surgery 
B)  Out-patient warfarin monitoring on stabilized patients 
C)  Confirmation testing for VWD following a prolonged APTT result 
D)  Rapid screening of platelet function for patients on aspirin therapy

Question 6

In testing for thrombotic disorders, the ideal test would be:

Accepted Answer

A)  Antigenic measurement of PC, PS, ATIII 
B)  Functional measurement of PC, PS, ATIII 
C)  Platelet function test 
D)  Lupus anticoagulant 
A)  Antigenic measurement of PC, PS, ATIII 
B)  Functional measurement of PC, PS, ATIII 
C)  Platelet function test 
D)  Lupus anticoagulant

Question 7

A patient is admitted with prolonged epistaxis and prolonged bleeding from a recent tooth extraction. Initial screening workup reports prolonged APTT and BT, and abnormal aggregation on the PFA. Which of the following tests would not help define the disorder?

Accepted Answer

A)  von Willebrand's factor activity 
B)  von Willebrand's factor antigen 
C)  Factor VIII assay 
D)  Prothrombin time 
A)  von Willebrand's factor activity 
B)  von Willebrand's factor antigen 
C)  Factor VIII assay 
D)  Prothrombin time

Question 8

Choose the correct statement regarding chromogenic analysis in hemostasis testing from the following choices.

Accepted Answer

A)  Chromogenic analysis depends on the selected analyte's ability to cleave a chromophore. 
B)  Chromogenic analysis is not subject to preanalytical problems because of its mechanism of clot detection. 
C)  There is no difference between chromogenic analysis and electromechanical detection. 
D)  Chromogenic analysis depends on the optical detection of ball movement through a steel tube as a clot forms. 
A)  Chromogenic analysis depends on the selected analyte's ability to cleave a chromophore. 
B)  Chromogenic analysis is not subject to preanalytical problems because of its mechanism of clot detection. 
C)  There is no difference between chromogenic analysis and electromechanical detection. 
D)  Chromogenic analysis depends on the optical detection of ball movement through a steel tube as a clot forms.

Question 9

Each of the following is the purpose of the INR except:

Accepted Answer

A)  To standardize the patient's PT worldwide 
B)  To minimize variability of results between laboratories 
C)  To minimize variability of results between lots of thromboplastin 
D)  To correlate the PT with the aPTT 
A)  To standardize the patient's PT worldwide 
B)  To minimize variability of results between laboratories 
C)  To minimize variability of results between lots of thromboplastin 
D)  To correlate the PT with the aPTT

Question 10

Proper specimen collection for coagulation testing must be performed to eliminate contamination of substances that will interfere with the test results. Which of the following are considered contaminants for coagulation testing?

Accepted Answer

A)  Sodium citrate and heparin anticoagulant 
B)  Tissue factor and anticoagulant carryover 
C)  Air and tissue factor 
D)  High hematocrit and anticoagulant carryover 
A)  Sodium citrate and heparin anticoagulant 
B)  Tissue factor and anticoagulant carryover 
C)  Air and tissue factor 
D)  High hematocrit and anticoagulant carryover

Question 11

The platelet function analyzer standardized the bleeding time method by eliminating the variables of the method. Which of the following represents the variables of bleeding time?

Accepted Answer

A)  Dependence on the presence of calcium 
B)  Ingestion of aspirin 
C)  Room temperature, depth, location and direction of the incision; movement of the arm, and laboratician experience 
D)  Abnormal platelet count 
A)  Dependence on the presence of calcium 
B)  Ingestion of aspirin 
C)  Room temperature, depth, location and direction of the incision; movement of the arm, and laboratician experience 
D)  Abnormal platelet count

Question 12

A patient has prolonged PT and APTT. Which of the following tests would not be warranted to follow up these findings?

Accepted Answer

A)  Factor XIII assay 
B)  D-dimer 
C)  Liver function tests 
D)  Fibrinogen 
A)  Factor XIII assay 
B)  D-dimer 
C)  Liver function tests 
D)  Fibrinogen

Question 13

The results of platelet-rich plasma (PRP) in the aggregation studies of a patient's blood were typical of ristocetin-induced platelet agglutination (RIPA) defect. The RIPA defect was corrected by adding normal plasma to the patient's PRP. In what disease is this seen?

Accepted Answer

A)  Sticky platelet syndrome 
B)  Bernard-Soulier syndrome 
C)  Afibrinogenemia 
D)  von Willebrand's disease 
A)  Sticky platelet syndrome 
B)  Bernard-Soulier syndrome 
C)  Afibrinogenemia 
D)  von Willebrand's disease

Question 14

According to the International Society on Thrombosis (ISTH), the guidelines for diagnostic criteria for LA/aPL include the demonstration of which of the following?

Accepted Answer

A)  Normal phospholipid-dependent coagulation reaction 
B)  Absence of a clotting factor 
C)  Presence of an inhibitor 
D)  Abnormal PT 
A)  Normal phospholipid-dependent coagulation reaction 
B)  Absence of a clotting factor 
C)  Presence of an inhibitor 
D)  Abnormal PT

Question 15

Give the results (prolonged or normal) for the bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time for a patient on prolonged anticoagulant therapy.

Accepted Answer

a. BT: Bleeding time assesses primary he

Question 16

Which of the following instruments is capable of performing electromechanical, optical density, chromogenic, and immunologic methodologies?

Accepted Answer

A)  STArt 4 
B)  Destiny Plus 
C)  STA Compact 
D)  Coag-A-Mate XM 
A)  STArt 4 
B)  Destiny Plus 
C)  STA Compact 
D)  Coag-A-Mate XM

Question 17

Which of the following tests does not measure activation of the hemostatic mechanism using markers of fibrin formation and fibrinolysis?

Accepted Answer

A)  Fibrinopeptide C and fibrinopeptide F 
B)  Thrombin-antithrombin (TAT) complex 
C)  Prothrombin activation fragment F1 + 2 
D)  Plasmin-antiplasmin (PAP) complex 
A)  Fibrinopeptide C and fibrinopeptide F 
B)  Thrombin-antithrombin (TAT) complex 
C)  Prothrombin activation fragment F1 + 2 
D)  Plasmin-antiplasmin (PAP) complex

Question 18

Which of the following is measured immunologically on the Diagnostica Stago STA Compact?

Accepted Answer

A)  von Willebrand factor 
B)  D-dimer 
C)  Lupus anticoagulants 
D)  PT and APTT 
A)  von Willebrand factor 
B)  D-dimer 
C)  Lupus anticoagulants 
D)  PT and APTT

Question 19

Explain the clinical significance of a prolonged time with each of the following:
a. Bleeding time
b. Prothrombin time
c. Activated partial thromboplastin time
d. Thrombin time

Accepted Answer

a. Bleeding time: Indicates a potential

Question 20

Laboratory screening test results strongly suggest heparin contamination. Which of the following tests would help assess this finding?

Accepted Answer

A)  DRVVT 
B)  Reptilase time 
C)  APTT 
D)  AT III activity 
A)  DRVVT 
B)  Reptilase time 
C)  APTT 
D)  AT III activity

Exam 36: Hemostasis: Laboratory Testing and Instrumentation

Thrombin time is prolonged with a patient who has:

Which of the following is the most appropriate reflex test based on the following laboratory data? PT: normal APTT: prolonged Factor VIII: C assay: <1%

An analyzer is measuring a clot forming by the interaction of a stationary probe with a moving probe in a continuous motion. Suddenly the moving probe stops, and a clot is seen. Name the analyzer.

Which of the following is needed to perform an activated partial thromboplastin time?

POC coagulation testing is beneficial in all of the following situations except:

In testing for thrombotic disorders, the ideal test would be:

A patient is admitted with prolonged epistaxis and prolonged bleeding from a recent tooth extraction. Initial screening workup reports prolonged APTT and BT, and abnormal aggregation on the PFA. Which of the following tests would not help define the disorder?

Choose the correct statement regarding chromogenic analysis in hemostasis testing from the following choices.

Each of the following is the purpose of the INR except:

Proper specimen collection for coagulation testing must be performed to eliminate contamination of substances that will interfere with the test results. Which of the following are considered contaminants for coagulation testing?

The platelet function analyzer standardized the bleeding time method by eliminating the variables of the method. Which of the following represents the variables of bleeding time?

A patient has prolonged PT and APTT. Which of the following tests would not be warranted to follow up these findings?

The results of platelet-rich plasma (PRP) in the aggregation studies of a patient's blood were typical of ristocetin-induced platelet agglutination (RIPA) defect. The RIPA defect was corrected by adding normal plasma to the patient's PRP. In what disease is this seen?

According to the International Society on Thrombosis (ISTH), the guidelines for diagnostic criteria for LA/aPL include the demonstration of which of the following?

Give the results (prolonged or normal) for the bleeding time, prothrombin time, activated partial thromboplastin time, and thrombin time for a patient on prolonged anticoagulant therapy.

Which of the following instruments is capable of performing electromechanical, optical density, chromogenic, and immunologic methodologies?

Which of the following tests does not measure activation of the hemostatic mechanism using markers of fibrin formation and fibrinolysis?

Which of the following is measured immunologically on the Diagnostica Stago STA Compact?

Explain the clinical significance of a prolonged time with each of the following: a. Bleeding time b. Prothrombin time c. Activated partial thromboplastin time d. Thrombin time

Laboratory screening test results strongly suggest heparin contamination. Which of the following tests would help assess this finding?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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