Exam 13: Hemoglobinopathies: Qualitative Defects

A patient's sample is run on cellulose acetate, and two bands are found. The first band migrates to the A region on the gel. The second band migrates to the S-D-G region on the band. What is the next step to identify the second band?

Which abnormal hemoglobin is slow moving and migrates closely with hemoglobin A2 on cellulose acetate at an alkaline pH?

The peripheral blood smear contains a normocytic, normochromic morphology with marked reticulocytosis. The hemoglobin solubility test is positive. What confirmatory test should follow?

In hemoglobin C disease, the cell's life span is decreased to what length?

The strength and type of charge on a hemoglobin molecule enables the separation of hemoglobin variants by electrophoresis. What other significant factor controls this separation?

What is the purpose of treating sickle cell patients with hydroxyurea?

Based on these findings, what test would be the logical next step?

Other than hemoglobin S, name two abnormal hemoglobins that produce a positive sickle solubility test. Explain how they could be differentiated from HbS.

Which of the following patients would have the highest percentage of hemoglobin S?

Thalassemias are produced as a result of:

All of the following parameters of the complete blood count are abnormal except:

Hemoglobinopathy results from a genetic abnormality of which structure within the hemoglobin molecule?

The net decrease in negative charge in the hemoglobin S molecule is responsible for which laboratory finding?

Hemoglobin C disease has altered solubility properties similar to hemoglobin S disease. What accounts for this altered solubility?

This patient presented with swollen hands and feet. This patient suffering from what kind of crisis?

How is methemoglobin detected in the laboratory?

A patient has a positive sickle solubility test. Further investigation reveals hemoglobin of 8.5 g/dL. What can be done to confirm these findings? Explain your answer.

What reflex test is most appropriate for investigating these results?

Based on the demographics of this patient, what disorder is suspected?

What preoperative therapy is effective in a diagnosed sickle cell patient?