Question 1

All of the following are related to the pathophysiology of multiple myeloma except:

Accepted Answer

A) Acceleration of plasma cells in the bone marrow 
B) Increased levels of tyrosine kinase activity 
C) Activation of osteoclasts 
D) Production of an abnormal monoclonal protein 
A) Acceleration of plasma cells in the bone marrow 
B) Increased levels of tyrosine kinase activity 
C) Activation of osteoclasts 
D) Production of an abnormal monoclonal protein B

Question 2

Which of the following genetic alterations is associated with a poor prognosis in CLL?

Accepted Answer

A) Trisomy 13 
B) Trisomy 12 
C) t(15:17) 
D) t(9:21) 
A) Trisomy 13 
B) Trisomy 12 
C) t(15:17) 
D) t(9:21) B

Question 3

Patients with CLL:

Accepted Answer

A) Die most often of blast crisis 
B) Are usually younger than 40 years 
C) May develop monoclonal spikes 
D) Often are immunocompromised 
A) Die most often of blast crisis 
B) Are usually younger than 40 years 
C) May develop monoclonal spikes 
D) Often are immunocompromised D

Question 4

The TRAP stain is useful in the diagnosis of:

Accepted Answer

A) CLL 
B) PLL 
C) Hairy cell leukemia 
D) Hodgkin's lymphoma 
A) CLL 
B) PLL 
C) Hairy cell leukemia 
D) Hodgkin's lymphoma

Question 5

Which of the following statements about Hodgkin's disease is false?

Accepted Answer

A) The peak incidence for the disease is 15 to 40 years of age. 
B) The disease occurs more frequently in males. 
C) It is a precursor to T-cell lymphoma 
D) Individuals who have been exposed to the Epstein-Barr virus may be more vulnerable to Hodgkin's lymphoma. 
A) The peak incidence for the disease is 15 to 40 years of age. 
B) The disease occurs more frequently in males. 
C) It is a precursor to T-cell lymphoma 
D) Individuals who have been exposed to the Epstein-Barr virus may be more vulnerable to Hodgkin's lymphoma.

Question 6

The most characteristic change seen in the peripheral smear of a patient with multiple myeloma is the presence of:

Accepted Answer

A) Microcytic hypochromic cells 
B) Intracellular inclusion bodies 
C) Rouleaux 
D) Agglutination 
A) Microcytic hypochromic cells 
B) Intracellular inclusion bodies 
C) Rouleaux 
D) Agglutination

Question 7

Lymphoma cells in the peripheral smear are associated with:

Accepted Answer

A) Hodgkin's lymphoma 
B) CLL 
C) non-Hodgkin's lymphoma 
D) Multiple myeloma 
A) Hodgkin's lymphoma 
B) CLL 
C) non-Hodgkin's lymphoma 
D) Multiple myeloma

Question 8

The immunoglobulin responsible for secondary immunological response and a monoclonal over-production in multiple myeloma is:

Accepted Answer

A) IgA 
B) IgM 
C) IgD 
D) IgG 
A) IgA 
B) IgM 
C) IgD 
D) IgG

Question 9

An abnormal proliferation of B lymphocytes seen in lymph node biopsy with a morphology resembling an owl's eye is commonly associated with:

Accepted Answer

A) Acute lymphocytic leukemia 
B) Chronic lymphocytic leukemia 
C) Infectious mononucleosis 
D) Hodgkin's disease 
A) Acute lymphocytic leukemia 
B) Chronic lymphocytic leukemia 
C) Infectious mononucleosis 
D) Hodgkin's disease

Question 10

Russell bodies are associated with:

Accepted Answer

A) Multiple myeloma 
B) Hodgkin's lymphoma 
C) Non-Hodgkin's lymphoma 
D) Waldenström's macroglobulinemia 
A) Multiple myeloma 
B) Hodgkin's lymphoma 
C) Non-Hodgkin's lymphoma 
D) Waldenström's macroglobulinemia

Question 11

A peripheral blood picture dominated by mature lymphocytes that resemble nucleated red blood cells would most likely be seen in:

Accepted Answer

A) Sézary syndrome 
B) Burkitt's lymphoma 
C) CLL 
D) Infectious mononucleosis 
A) Sézary syndrome 
B) Burkitt's lymphoma 
C) CLL 
D) Infectious mononucleosis

Question 12

The CD markers associated with CLL include all of the following except:

Accepted Answer

A) CD 4 
B) CD 15 
C) CD 19 
D) CD 20 
A) CD 4 
B) CD 15 
C) CD 19 
D) CD 20

Question 13

A significant feature of hairy cell leukemia not seen is other acute leukemias is:

Accepted Answer

A) Panmyelosis 
B) Pancytosis 
C) Pancytopenia 
D) Panhyperplasia 
A) Panmyelosis 
B) Pancytosis 
C) Pancytopenia 
D) Panhyperplasia

Question 14

Hypogammaglobulinemia is a significant feature in half of patients with CLL.This complication can lead to:

Accepted Answer

A) Refractory anemia 
B) Essential thrombocytosis 
C) Autoimmune hemolytic anemia 
D) Pernicious anemia 
A) Refractory anemia 
B) Essential thrombocytosis 
C) Autoimmune hemolytic anemia 
D) Pernicious anemia

Question 15

All of the following are consistent with the clinical and pathological picture of Waldenström's macroglobulinemia except:

Accepted Answer

A) M spike due to IgM 
B) Lymphadenopathy and splenomegaly 
C) Proliferation of lymphocytes and plasmacytoid lymphocytes 
D) Destructive bone lesions 
A) M spike due to IgM 
B) Lymphadenopathy and splenomegaly 
C) Proliferation of lymphocytes and plasmacytoid lymphocytes 
D) Destructive bone lesions

Question 16

Which of the following statements is true about chronic lymphoproliferative disorders?

Accepted Answer

A) Complications are related to overactive immune systems. 
B) They are often seen in elderly patients and progress quickly. 
C) They are often seen in elderly patients and progress slowly. 
D) They are a clonal proliferation of granulocytes. 
A) Complications are related to overactive immune systems. 
B) They are often seen in elderly patients and progress quickly. 
C) They are often seen in elderly patients and progress slowly. 
D) They are a clonal proliferation of granulocytes.

Question 17

A new treatment for multiple myeloma that was once banned from use in pregnant women is:

Accepted Answer

A) EPO 
B) Thalidomide 
C) Demerol 
D) Interferon 
A) EPO 
B) Thalidomide 
C) Demerol 
D) Interferon

Question 18

All of the following describe characteristics of a plasma cell except:

Accepted Answer

A) Medium-sized cell 
B) Eccentric nucleus 
C) Well-defined Golgi apparatus 
D) Very little, light blue cytoplasm 
A) Medium-sized cell 
B) Eccentric nucleus 
C) Well-defined Golgi apparatus 
D) Very little, light blue cytoplasm

All of the following are related to the pathophysiology of multiple myeloma except:

Which of the following genetic alterations is associated with a poor prognosis in CLL?

Patients with CLL:

The TRAP stain is useful in the diagnosis of:

Which of the following statements about Hodgkin's disease is false?

The most characteristic change seen in the peripheral smear of a patient with multiple myeloma is the presence of:

Lymphoma cells in the peripheral smear are associated with:

The immunoglobulin responsible for secondary immunological response and a monoclonal over-production in multiple myeloma is:

An abnormal proliferation of B lymphocytes seen in lymph node biopsy with a morphology resembling an owl's eye is commonly associated with:

Russell bodies are associated with:

A peripheral blood picture dominated by mature lymphocytes that resemble nucleated red blood cells would most likely be seen in:

The CD markers associated with CLL include all of the following except:

A significant feature of hairy cell leukemia not seen is other acute leukemias is:

Hypogammaglobulinemia is a significant feature in half of patients with CLL.This complication can lead to:

All of the following are consistent with the clinical and pathological picture of Waldenström's macroglobulinemia except:

Which of the following statements is true about chronic lymphoproliferative disorders?

A new treatment for multiple myeloma that was once banned from use in pregnant women is:

All of the following describe characteristics of a plasma cell except:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 13: Lymphoproliferative Disorders and Related Plasma Cell Disorders

All of the following are related to the pathophysiology of multiple myeloma except:

Which of the following genetic alterations is associated with a poor prognosis in CLL?

Patients with CLL:

The TRAP stain is useful in the diagnosis of:

Which of the following statements about Hodgkin's disease is false?

The most characteristic change seen in the peripheral smear of a patient with multiple myeloma is the presence of:

Lymphoma cells in the peripheral smear are associated with:

The immunoglobulin responsible for secondary immunological response and a monoclonal over-production in multiple myeloma is:

An abnormal proliferation of B lymphocytes seen in lymph node biopsy with a morphology resembling an owl's eye is commonly associated with:

Russell bodies are associated with:

A peripheral blood picture dominated by mature lymphocytes that resemble nucleated red blood cells would most likely be seen in:

The CD markers associated with CLL include all of the following except:

A significant feature of hairy cell leukemia not seen is other acute leukemias is:

Hypogammaglobulinemia is a significant feature in half of patients with CLL.This complication can lead to:

All of the following are consistent with the clinical and pathological picture of Waldenström's macroglobulinemia except:

Which of the following statements is true about chronic lymphoproliferative disorders?

A new treatment for multiple myeloma that was once banned from use in pregnant women is:

All of the following describe characteristics of a plasma cell except:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters