Question 1

All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?

Accepted Answer

A) Partial gastrectomy may lead to the lack of IF. 
B) Fifty-six percent of patients with pernicious anemia have antibodies to IF. 
C) Atrophic gastritis may lead to the lack of IF. 
D) Kidney failure may lead to lack of IF. 
A) Partial gastrectomy may lead to the lack of IF. 
B) Fifty-six percent of patients with pernicious anemia have antibodies to IF. 
C) Atrophic gastritis may lead to the lack of IF. 
D) Kidney failure may lead to lack of IF. D

Question 2

One of the most common pathophysiologies that contribute to folic acid deficiency is:

Accepted Answer

A) Tropical sprue 
B) Intrinsic factor deficiency 
C) IDA 
D) Infection with Diphyllobothrium latum 
A) Tropical sprue 
B) Intrinsic factor deficiency 
C) IDA 
D) Infection with Diphyllobothrium latum A

Question 3

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Accepted Answer

A) Chemotherapy 
B) Postsplenectomy 
C) Hypoglycemic patients 
D) Reticulocytosis 
A) Chemotherapy 
B) Postsplenectomy 
C) Hypoglycemic patients 
D) Reticulocytosis C

Question 4

Which of the following can distinguish treated versus untreated megaloblastic anemia?

Accepted Answer

A) Polychromasia 
B) Hypochromia 
C) Howell-Jolly bodies 
D) Siderocytes 
A) Polychromasia 
B) Hypochromia 
C) Howell-Jolly bodies 
D) Siderocytes

Question 5

The Schilling test continues to be a historic reference method for the determination of:

Accepted Answer

A) IDA 
B) Pernicious anemia 
C) Folic acid deficiency 
D) Hereditary hemochromatosis 
A) IDA 
B) Pernicious anemia 
C) Folic acid deficiency 
D) Hereditary hemochromatosis

Question 6

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Accepted Answer

A) 1:3 
B) 4:1 
C) 5:1 
D) 1:10 
A) 1:3 
B) 4:1 
C) 5:1 
D) 1:10

Question 7

Intrinsic factor is secreted by the:

Accepted Answer

A) Parietal cells of the stomach 
B) Ileum 
C) Thyroid 
D) Bone marrow 
A) Parietal cells of the stomach 
B) Ileum 
C) Thyroid 
D) Bone marrow

Question 8

Macrocytic red blood cells are routinely seen in all the following except:

Accepted Answer

A) Pernicious anemia 
B) Liver disease 
C) Response to anemic stress 
D) Thalassemia 
A) Pernicious anemia 
B) Liver disease 
C) Response to anemic stress 
D) Thalassemia

Question 9

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Accepted Answer

A) Ordered arrangement of chromatin 
B) Asynchrony 
C) Eccentric nucleus 
D) Pale cytoplasm 
A) Ordered arrangement of chromatin 
B) Asynchrony 
C) Eccentric nucleus 
D) Pale cytoplasm

Question 10

Which MCV range is indicative of pernicious anemia?

Accepted Answer

A) 70 to 80 fL 
B) 85 to 95 fL 
C) 110 to 120 fL 
D) 90 to 98 fL 
A) 70 to 80 fL 
B) 85 to 95 fL 
C) 110 to 120 fL 
D) 90 to 98 fL

Question 11

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Accepted Answer

A) Polychromasia 
B) Macroovalocytes 
C) Basophilic stippling 
D) Hypochromia 
A) Polychromasia 
B) Macroovalocytes 
C) Basophilic stippling 
D) Hypochromia

Question 12

Which of the following is a clinical symptom specific to megaloblastic anemia?

Accepted Answer

A) Fever 
B) Numbness and trouble with balance 
C) Pallor 
D) Splenomegaly 
A) Fever 
B) Numbness and trouble with balance 
C) Pallor 
D) Splenomegaly

Question 13

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

Accepted Answer

A) Anemia, thrombocytopenia, leukopenia. 
B) Anemia, thrombocytosis, leukopenia . 
C) Anemia, thrombophilia , leukocytosis 
D) anemia, thrombocytosis, leukopenia 
A) Anemia, thrombocytopenia, leukopenia. 
B) Anemia, thrombocytosis, leukopenia . 
C) Anemia, thrombophilia , leukocytosis 
D) anemia, thrombocytosis, leukopenia

Question 14

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Accepted Answer

A) True 
 B)False

Question 15

Which of the following describes ineffective erythropoiesis?

Accepted Answer

A) An increase in the M:E ratio 
B) A synthetic defect in hemoglobin 
C) Premature destruction of red blood cell precursors 
D) A DNA maturation defect 
A) An increase in the M:E ratio 
B) A synthetic defect in hemoglobin 
C) Premature destruction of red blood cell precursors 
D) A DNA maturation defect

Question 16

Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?

Accepted Answer

A) EPO 
B) Transferrin 
C) Intrinsic factor 
D) Cytokines 
A) EPO 
B) Transferrin 
C) Intrinsic factor 
D) Cytokines

All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?

One of the most common pathophysiologies that contribute to folic acid deficiency is:

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Which of the following can distinguish treated versus untreated megaloblastic anemia?

The Schilling test continues to be a historic reference method for the determination of:

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Intrinsic factor is secreted by the:

Macrocytic red blood cells are routinely seen in all the following except:

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Which MCV range is indicative of pernicious anemia?

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Which of the following is a clinical symptom specific to megaloblastic anemia?

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Which of the following describes ineffective erythropoiesis?

Which of the following is a key substance required for the incorporation of vitamin B₁₂ in the nuclear synthesis of red blood cells?

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 6: The Macrocytic Anemias

All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?

One of the most common pathophysiologies that contribute to folic acid deficiency is:

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Which of the following can distinguish treated versus untreated megaloblastic anemia?

The Schilling test continues to be a historic reference method for the determination of:

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Intrinsic factor is secreted by the:

Macrocytic red blood cells are routinely seen in all the following except:

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Which MCV range is indicative of pernicious anemia?

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Which of the following is a clinical symptom specific to megaloblastic anemia?

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Which of the following describes ineffective erythropoiesis?

Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Which of the following is a key substance required for the incorporation of vitamin B₁₂ in the nuclear synthesis of red blood cells?