Question 1

Which organ(s) is(are) the most affected during extravascular lysis?

Accepted Answer

A) Liver and spleen 
B) Kidneys 
C) Pancreas 
D) Heart 
A) Liver and spleen 
B) Kidneys 
C) Pancreas 
D) Heart A

Question 2

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Accepted Answer

A) 65% 
B) 95% 
C) 35% 
D) 45% 
A) 65% 
B) 95% 
C) 35% 
D) 45% C

Question 3

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

Accepted Answer

A) Increased pH 
B) Increased altitude 
C) Increased 2,3-DPG 
D) Increased carboxyhemoglobin 
A) Increased pH 
B) Increased altitude 
C) Increased 2,3-DPG 
D) Increased carboxyhemoglobin C

Question 4

When iron is present in an oxidized state as Fe+3 or ferric iron, the resulting hemoglobin is known as:

Accepted Answer

A) Methemoglobin 
B) Carboxyhemoglobin 
C) Sulfhemoglobin 
D) Deoxyhemoglobin 
A) Methemoglobin 
B) Carboxyhemoglobin 
C) Sulfhemoglobin 
D) Deoxyhemoglobin

Question 5

Hemoglobin begins to be synthesized at the polychromatophilic stage of red blood cell development.

Accepted Answer

A) True 
 B)False

Question 6

Fetal hemoglobin consists of which of the following chains?

Accepted Answer

A) α2β2 
B) α2γ2 
C) α2δ2 
D) α2ε2 
A) α2β2 
B) α2γ2 
C) α2δ2 
D) α2ε2

Question 7

Intrinsic red cell defects that can lead to hemolysis include:

Accepted Answer

A) Environmental effects 
B) Inherited deficiencies 
C) A shift in pH 
D) A decrease in G6PD 
A) Environmental effects 
B) Inherited deficiencies 
C) A shift in pH 
D) A decrease in G6PD

Question 8

Epsilon and zeta chains are part of which of the following hemoglobins?

Accepted Answer

A) Hemoglobin Portland 
B) Hemoglobin F 
C) Hemoglobin A 
D) Hemoglobin A2 
A) Hemoglobin Portland 
B) Hemoglobin F 
C) Hemoglobin A 
D) Hemoglobin A2

Question 9

Each hemoglobin molecule consists of four ____ .

Accepted Answer

A) alpha chain molecules 
B) beta chain molecules 
C) heme molecules with with Fe2+ 
D) heme molecules with Fe3+ 
A) alpha chain molecules 
B) beta chain molecules 
C) heme molecules with with Fe2+ 
D) heme molecules with Fe3+

Question 10

Physiological conditions in the body that can decrease hemoglobin's oxygen affinity include:

Accepted Answer

A) Increased pH 
B) Decreased 2,3-DPG 
C) Increased body temperature 
D) The presence of abnormal hemoglobins 
A) Increased pH 
B) Decreased 2,3-DPG 
C) Increased body temperature 
D) The presence of abnormal hemoglobins

Question 11

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Accepted Answer

A) Sulfhemoglobin 
B) Cyanmethemoglobin 
C) Hemoglobin F 
D) Hemoglobin M 
A) Sulfhemoglobin 
B) Cyanmethemoglobin 
C) Hemoglobin F 
D) Hemoglobin M

Question 12

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Accepted Answer

A) Bilirubinemia 
B) Decreased RBC count 
C) Hemoglobinuria 
D) Elevated LDH 
A) Bilirubinemia 
B) Decreased RBC count 
C) Hemoglobinuria 
D) Elevated LDH

Question 13

Oxygen delivery is the primary purpose of hemoglobin.

Accepted Answer

A) True 
 B)False

Question 14

Ninety percent of in vivo hemolysis is intravascular.

Accepted Answer

A) True 
 B)False

Question 15

Which of the following is not a normal adult hemoglobin?

Accepted Answer

A) Hgb A 
B) Hgb Portland 
C) Hgb F 
D) Hgb A2 
A) Hgb A 
B) Hgb Portland 
C) Hgb F 
D) Hgb A2

Question 16

Abnormal hemoglobins have a lower affinity for oxygen.

Accepted Answer

A) True 
 B)False

Question 17

________ may be seen in intravascular hemolysis but not in extravascular hemolysis.

Accepted Answer

A) Hemoglobinuria 
B) Splenomegaly 
C) Increased LDH 
D) Elevated serum bilirubin 
A) Hemoglobinuria 
B) Splenomegaly 
C) Increased LDH 
D) Elevated serum bilirubin

Question 18

How many genes are responsible for the productions of alpha chains?

Accepted Answer

A) Two 
B) One 
C) Three 
D) Four 
A) Two 
B) One 
C) Three 
D) Four

Question 19

Which of the following variables affect how the hemoglobin molecule either holds on to or releases oxygen?

Accepted Answer

A) Amount of alpha or beta chains 
B) Relationship between the pulmonary and venous circulations 
C) Viscosity of the blood 
D) Ferritin levels 
A) Amount of alpha or beta chains 
B) Relationship between the pulmonary and venous circulations 
C) Viscosity of the blood 
D) Ferritin levels

Question 20

Each hemoglobin molecule consists of ____ globin structures.

Accepted Answer

A) two 
B) four 
C) six 
D) eight 
A) two 
B) four 
C) six 
D) eight

Which organ(s) is(are) the most affected during extravascular lysis?

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

When iron is present in an oxidized state as Fe⁺³ or ferric iron, the resulting hemoglobin is known as:

Hemoglobin begins to be synthesized at the polychromatophilic stage of red blood cell development.

Fetal hemoglobin consists of which of the following chains?

Intrinsic red cell defects that can lead to hemolysis include:

Epsilon and zeta chains are part of which of the following hemoglobins?

Each hemoglobin molecule consists of four ____ .

Physiological conditions in the body that can decrease hemoglobin's oxygen affinity include:

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Oxygen delivery is the primary purpose of hemoglobin.

Ninety percent of in vivo hemolysis is intravascular.

Which of the following is not a normal adult hemoglobin?

Abnormal hemoglobins have a lower affinity for oxygen.

________ may be seen in intravascular hemolysis but not in extravascular hemolysis.

How many genes are responsible for the productions of alpha chains?

Which of the following variables affect how the hemoglobin molecule either holds on to or releases oxygen?

Each hemoglobin molecule consists of ____ globin structures.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 4: Hemoglobin Function and Principles of Hemolysis

Which organ(s) is(are) the most affected during extravascular lysis?

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

When iron is present in an oxidized state as Fe+3 or ferric iron, the resulting hemoglobin is known as:

Hemoglobin begins to be synthesized at the polychromatophilic stage of red blood cell development.

Fetal hemoglobin consists of which of the following chains?

Intrinsic red cell defects that can lead to hemolysis include:

Epsilon and zeta chains are part of which of the following hemoglobins?

Each hemoglobin molecule consists of four ____ .

Physiological conditions in the body that can decrease hemoglobin's oxygen affinity include:

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Oxygen delivery is the primary purpose of hemoglobin.

Ninety percent of in vivo hemolysis is intravascular.

Which of the following is not a normal adult hemoglobin?

Abnormal hemoglobins have a lower affinity for oxygen.

________ may be seen in intravascular hemolysis but not in extravascular hemolysis.

How many genes are responsible for the productions of alpha chains?

Which of the following variables affect how the hemoglobin molecule either holds on to or releases oxygen?

Each hemoglobin molecule consists of ____ globin structures.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

When iron is present in an oxidized state as Fe⁺³ or ferric iron, the resulting hemoglobin is known as: