Question 1

What is the most common infectious cause of congenital neonatal megakaryocytic hypoplasia?

Accepted Answer

A) Epstein-Barr virus 
B) human immunodeficiency virus (HIV) 
C) cytomegalovirus 
D) rubella 
A) Epstein-Barr virus 
B) human immunodeficiency virus (HIV) 
C) cytomegalovirus 
D) rubella C

Question 2

A 28-year-old woman sees her family physician complaining of easy bruising and menorrhagia.She has a platelet count of 60 × 10⁹/L.All other hematology and routine coagulation tests are normal.She has a platelet-associated immunoglobulin G (IgG)autoantibody in her serum.Which of the following is most likely?

Accepted Answer

A) chronic immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) acute immune thrombocytopenic purpura 
D) hemolytic uremic syndrome 
A) chronic immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) acute immune thrombocytopenic purpura 
D) hemolytic uremic syndrome A

Question 3

Which of the following is successfully treated with plasmapheresis?

Accepted Answer

A) immune thrombocytopenic purpura 
B) chronic DIC 
C) acute DIC 
D) thrombotic thrombocytopenic purpura 
A) immune thrombocytopenic purpura 
B) chronic DIC 
C) acute DIC 
D) thrombotic thrombocytopenic purpura D

Question 4

What is the single most common cause of clinically important bleeding?

Accepted Answer

A) hemophilia 
B) fibrinogen deficiency 
C) thrombocytopenia 
D) qualitative platelet disorders 
A) hemophilia 
B) fibrinogen deficiency 
C) thrombocytopenia 
D) qualitative platelet disorders

Question 5

All of the following are often associated with thrombocytosis except

Accepted Answer

A) hemorrhage 
B) alcoholic liver disease 
C) iron deficiency 
D) inflammation 
A) hemorrhage 
B) alcoholic liver disease 
C) iron deficiency 
D) inflammation

Question 6

What is believed to be the cause for acute immune thrombocytopenia purpura in children?

Accepted Answer

A) development of a platelet-specific autoantibody 
B) development of a white cell autoantibody that cross-reacts with platelet membrane antigens 
C) development of an allogeneic antibody after transfusion of random allogeneic platelets 
D) nonspecific binding of immune complexes to the platelet membrane after a viral illness 
A) development of a platelet-specific autoantibody 
B) development of a white cell autoantibody that cross-reacts with platelet membrane antigens 
C) development of an allogeneic antibody after transfusion of random allogeneic platelets 
D) nonspecific binding of immune complexes to the platelet membrane after a viral illness

Question 7

What is the correct term to describe a platelet count of 550 × 10⁹/L when all other complete blood count (CBC)results are basically normal?

Accepted Answer

A) normal 
B) thrombocytosis 
C) thrombocytopenia 
D) essential thrombocythemia 
A) normal 
B) thrombocytosis 
C) thrombocytopenia 
D) essential thrombocythemia

Question 8

Which of the following is an example of a quantitative platelet disorder related to distribution?

Accepted Answer

A) thrombotic cytopenic purpura 
B) essential thrombocythemia 
C) splenomegaly 
D) hemolytic uremic syndrome 
A) thrombotic cytopenic purpura 
B) essential thrombocythemia 
C) splenomegaly 
D) hemolytic uremic syndrome

Question 9

A 23-year-old man is brought by helicopter to a major trauma center after a severe motorcycle accident.He has major abdominal trauma,including a ruptured spleen,and is taken to surgery,where his spleen is removed.Two weeks after surgery,his platelet count peaks at 950 × 10⁹/L.What is the most likely cause for this high platelet count?

Accepted Answer

A) reactive thrombocytosis secondary to trauma 
B) essential thrombocythemia 
C) postsplenectomy thrombocytosis 
D) reactive thrombocytosis secondary to acute blood loss 
A) reactive thrombocytosis secondary to trauma 
B) essential thrombocythemia 
C) postsplenectomy thrombocytosis 
D) reactive thrombocytosis secondary to acute blood loss

Question 10

Which of the following results in ineffective thrombopoiesis?

Accepted Answer

A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) disseminated intravascular coagulation (DI
C)  
D) megaloblastic anemia 
A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) disseminated intravascular coagulation (DI
C)  
D) megaloblastic anemia

Question 11

An enzyme-linked immunosorbent assay (ELISA)with platelet factor 4 (PF4)coated to the surface of microplate wells is used for the diagnosis of

Accepted Answer

A) heparin-induced thrombocytopenia. 
B) acute immune thrombocytopenic purpura. 
C) chronic immune thrombocytopenic purpura. 
D) aspirin resistance. 
A) heparin-induced thrombocytopenia. 
B) acute immune thrombocytopenic purpura. 
C) chronic immune thrombocytopenic purpura. 
D) aspirin resistance.

Question 12

Chemotherapy results in which of the following?

Accepted Answer

A) acquired hypoplastic thrombocytopenia 
B) acquired immune thrombocytopenia 
C) acquired splenic sequestration 
D) inherited nonimmune thrombocythemia 
A) acquired hypoplastic thrombocytopenia 
B) acquired immune thrombocytopenia 
C) acquired splenic sequestration 
D) inherited nonimmune thrombocythemia

Question 13

What is the probable cause for thrombotic thrombocytopenic purpura?

Accepted Answer

A) deficiency of a metalloprotease needed to enzymatically degrade unusually large von Willebrand factor (VWF) multimers 
B) abnormal synthesis of unusually large VWF multimers by endothelial cells 
C) abnormal synthesis of unusually large VWF multimers by megakaryocytes 
D) abnormal complexing of normal VWF multimers to create unusually large VWF multimers 
A) deficiency of a metalloprotease needed to enzymatically degrade unusually large von Willebrand factor (VWF) multimers 
B) abnormal synthesis of unusually large VWF multimers by endothelial cells 
C) abnormal synthesis of unusually large VWF multimers by megakaryocytes 
D) abnormal complexing of normal VWF multimers to create unusually large VWF multimers

Question 14

Which of the following is a commonly used drug that can cause thrombocytopenia?

Accepted Answer

A) warfarin 
B) aspirin 
C) ibuprofen 
D) heparin 
A) warfarin 
B) aspirin 
C) ibuprofen 
D) heparin

Question 15

A 4-year-old child becomes very sick after eating undercooked ground beef.Kidney function tests are very elevated.Thrombocytopenia is mild,and a few schistocytes are noted on the blood film.Which of the following is most likely diagnosis?

Accepted Answer

A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) hemolytic uremic syndrome 
D) DIC 
A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) hemolytic uremic syndrome 
D) DIC

Question 16

The terms petechiae,purpura,and ecchymoses all describe

Accepted Answer

A) varying degrees of thrombocytopenia. 
B) varying degrees of thrombocythemia. 
C) varying qualitative platelet disorders. 
D) varying size hemorrhages into the skin because of small-vessel bleeding. 
A) varying degrees of thrombocytopenia. 
B) varying degrees of thrombocythemia. 
C) varying qualitative platelet disorders. 
D) varying size hemorrhages into the skin because of small-vessel bleeding.

Question 17

A 35-year-old woman with neurologic symptoms presents with a markedly decreased platelet count.She has moderate anemia with many red cell fragments on the blood film,as well as polychromasia and nucleated red blood cells (RBCs).The prothrombin time (PT)and partial thromboplastin time (PTT)are both normal.Which of the following is most likely diagnosis?

Accepted Answer

A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) hemolytic uremic syndrome 
D) DIC 
A) immune thrombocytopenic purpura 
B) thrombotic thrombocytopenic purpura 
C) hemolytic uremic syndrome 
D) DIC

Question 18

What are the primary clinical manifestations of essential thrombocythemia?

Accepted Answer

A) platelet dysfunction 
B) hemorrhage 
C) thrombosis 
D) all of the above 
A) platelet dysfunction 
B) hemorrhage 
C) thrombosis 
D) all of the above

Question 19

Which of the following patient groups is most commonly diagnosed with acute immune thrombocytopenic purpura?

Accepted Answer

A) older men after an infection 
B) infants born to women who had eclampsia 
C) children after having an infection 
D) adult patients with enlarged spleens 
A) older men after an infection 
B) infants born to women who had eclampsia 
C) children after having an infection 
D) adult patients with enlarged spleens

Question 20

What kind of antibody causes neonatal alloimmune thrombocytopenia?

Accepted Answer

A) maternal antibody against a fetal platelet antigen inherited from the father 
B) fetal antibody directed against maternal platelet antigen 
C) fetal antibody against a fetal platelet antigen inherited from the father 
D) maternal autoantibody against a mother's platelet antigen 
A) maternal antibody against a fetal platelet antigen inherited from the father 
B) fetal antibody directed against maternal platelet antigen 
C) fetal antibody against a fetal platelet antigen inherited from the father 
D) maternal autoantibody against a mother's platelet antigen

Exam 40: Thrombocytopenia and Thrombocytosis

What is the most common infectious cause of congenital neonatal megakaryocytic hypoplasia?

Which of the following is successfully treated with plasmapheresis?

What is the single most common cause of clinically important bleeding?

All of the following are often associated with thrombocytosis except

What is believed to be the cause for acute immune thrombocytopenia purpura in children?

What is the correct term to describe a platelet count of 550 × 10⁹/L when all other complete blood count (CBC)results are basically normal?

Which of the following is an example of a quantitative platelet disorder related to distribution?

Which of the following results in ineffective thrombopoiesis?

An enzyme-linked immunosorbent assay (ELISA)with platelet factor 4 (PF4)coated to the surface of microplate wells is used for the diagnosis of

Chemotherapy results in which of the following?

What is the probable cause for thrombotic thrombocytopenic purpura?

Which of the following is a commonly used drug that can cause thrombocytopenia?

A 4-year-old child becomes very sick after eating undercooked ground beef.Kidney function tests are very elevated.Thrombocytopenia is mild,and a few schistocytes are noted on the blood film.Which of the following is most likely diagnosis?

The terms petechiae,purpura,and ecchymoses all describe

What are the primary clinical manifestations of essential thrombocythemia?

Which of the following patient groups is most commonly diagnosed with acute immune thrombocytopenic purpura?

What kind of antibody causes neonatal alloimmune thrombocytopenia?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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