Question 1

Thick blood films for malaria diagnosis are best used for which purpose?

Accepted Answer

A) initial screening 
B) determination of the percent of parasitemia 
C) speciation 
D) identification of stages 
A) initial screening 
B) determination of the percent of parasitemia 
C) speciation 
D) identification of stages A

Question 2

Why does Plasmodium falciparum infection result in the most serious hemolysis of the various forms of malaria?

Accepted Answer

A) Only reticulocytes are invaded. 
B) Reticulocytes and RBCs less than 10 days old are invaded. 
C) Only mature RBCs are invaded. 
D) RBCs of all ages are invaded. 
A) Only reticulocytes are invaded. 
B) Reticulocytes and RBCs less than 10 days old are invaded. 
C) Only mature RBCs are invaded. 
D) RBCs of all ages are invaded. D

Question 3

Renal failure is a prominent feature of

Accepted Answer

A) hemolytic uremic syndrome. 
B) thrombotic thrombocytopenic purpura. 
C) Plasmodium malariae infection. 
D) march hemoglobinuria. 
A) hemolytic uremic syndrome. 
B) thrombotic thrombocytopenic purpura. 
C) Plasmodium malariae infection. 
D) march hemoglobinuria. A

Question 4

A patient's red cells show globular fragmentation,budding,and microspherocytes.To what have the red cells probably been exposed?

Accepted Answer

A) heat 
B) chemicals 
C) oxidant drugs 
D) bartonellosis 
A) heat 
B) chemicals 
C) oxidant drugs 
D) bartonellosis

Question 5

Which of the following decreases the ability of malaria species to infect RBCs?

Accepted Answer

A) Duffy-positive phenotype 
B) heterozygosity for hemoglobin S (Hb S) 
C) hereditary spherocytosis 
D) Rh-negative genotype 
A) Duffy-positive phenotype 
B) heterozygosity for hemoglobin S (Hb S) 
C) hereditary spherocytosis 
D) Rh-negative genotype

Question 6

MAHA is often secondary to all of the following conditions except

Accepted Answer

A) infections, especially sepsis. 
B) obstetric complications. 
C) renal disease. 
D) cancer. 
A) infections, especially sepsis. 
B) obstetric complications. 
C) renal disease. 
D) cancer.

Question 7

A mild intravascular hemolytic anemia resulting from forceful repeated effect of the feet on hard surfaces is called

Accepted Answer

A) traumatic cardiac hemolytic anemia. 
B) exercise-induced hemoglobinuria. 
C) bartonellosis. 
D) thrombotic thrombocytopenic purpura. 
A) traumatic cardiac hemolytic anemia. 
B) exercise-induced hemoglobinuria. 
C) bartonellosis. 
D) thrombotic thrombocytopenic purpura.

Question 8

Which of the following techniques most often diagnoses malaria and Babesia infections?

Accepted Answer

A) polymerase chain reaction (PCR) 
B) observing the organisms in blood films 
C) serologic tests 
D) culture 
A) polymerase chain reaction (PCR) 
B) observing the organisms in blood films 
C) serologic tests 
D) culture

Question 9

Which of the following infections is responsible for the most deaths worldwide?

Accepted Answer

A) malaria 
B) Babesia infection 
C) Bartonella infection 
D) clostridial septicemia 
A) malaria 
B) Babesia infection 
C) Bartonella infection 
D) clostridial septicemia

Question 10

All of the following are examples of microangiopathic hemolytic anemias (MAHAs)except

Accepted Answer

A) thrombotic thrombocytopenia purpura 
B) hemolytic uremic syndrome 
C) disseminated intravascular coagulation (DI
C)  
D) immune thrombocytopenia purpura 
A) thrombotic thrombocytopenia purpura 
B) hemolytic uremic syndrome 
C) disseminated intravascular coagulation (DI
C)  
D) immune thrombocytopenia purpura

Question 11

Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?

Accepted Answer

A) hemolytic uremic syndrome 
B) thrombotic thrombocytopenic purpura 
C) march hemoglobinuria 
D) DIC 
A) hemolytic uremic syndrome 
B) thrombotic thrombocytopenic purpura 
C) march hemoglobinuria 
D) DIC

Question 12

Which of the following is an expected finding in MAHA?

Accepted Answer

A) elevated platelets 
B) schistocytes or red cell fragments 
C) low white count 
D) extravascular hemolysis 
A) elevated platelets 
B) schistocytes or red cell fragments 
C) low white count 
D) extravascular hemolysis

Question 13

What is the pathogenesis of MAHA?

Accepted Answer

A) Microthrombi and fibrin formed on damaged endothelial cells trap and break red cells. 
B) Chemicals or heat destroy red blood cells (RBCs). 
C) The spleen sequesters red cells in an attempt to remove abnormal inclusions. 
D) Antibodies that activate complement are formed and destroy the red cell membrane. 
A) Microthrombi and fibrin formed on damaged endothelial cells trap and break red cells. 
B) Chemicals or heat destroy red blood cells (RBCs). 
C) The spleen sequesters red cells in an attempt to remove abnormal inclusions. 
D) Antibodies that activate complement are formed and destroy the red cell membrane.

Question 14

A patient has crescent- or banana-shaped malarial gametocytes.Which of the following is probably true regarding the species of malaria and its clinical course?

Accepted Answer

A) Plasmodium malariae, which is benign and needs no treatment 
B) Plasmodium ovale, which is found mostly in Southern United States and is usually fatal 
C) Plasmodium falciparum, which is the most clinically serious 
D) Plasmodium vivax, which is the most clinically serious 
A) Plasmodium malariae, which is benign and needs no treatment 
B) Plasmodium ovale, which is found mostly in Southern United States and is usually fatal 
C) Plasmodium falciparum, which is the most clinically serious 
D) Plasmodium vivax, which is the most clinically serious

Exam 25: Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Thick blood films for malaria diagnosis are best used for which purpose?

Why does Plasmodium falciparum infection result in the most serious hemolysis of the various forms of malaria?

Renal failure is a prominent feature of

A patient's red cells show globular fragmentation,budding,and microspherocytes.To what have the red cells probably been exposed?

Which of the following decreases the ability of malaria species to infect RBCs?

MAHA is often secondary to all of the following conditions except

A mild intravascular hemolytic anemia resulting from forceful repeated effect of the feet on hard surfaces is called

Which of the following techniques most often diagnoses malaria and Babesia infections?

Which of the following infections is responsible for the most deaths worldwide?

All of the following are examples of microangiopathic hemolytic anemias (MAHAs)except

Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?

Which of the following is an expected finding in MAHA?

What is the pathogenesis of MAHA?

A patient has crescent- or banana-shaped malarial gametocytes.Which of the following is probably true regarding the species of malaria and its clinical course?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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