Question 1

Match the ABC transporter with the respective number of TMDs.
MRP2

Accepted Answer

A)  7 
B)  13 
C)  18 
A)  7 
B)  13 
C)  18

Question 2

What type of database search programs are used in proteomics analysis?

Accepted Answer

A)  Mascot, http://www.matrixscience.com/ 
B)  Masslynx http://www.waters.com 
C)  MS-Tag/MS-Seq http://prospector.ucsf.edu/ 
D)  PeptideSearch http://www.narrador.embl-heidelberg.de/GroupPages/Homepage.html 
E)  PepFrag http://prowl.rockefeller.edu/PROWL
F) All of the above
G) None of the above 
A)  Mascot, http://www.matrixscience.com/ 
B)  Masslynx http://www.waters.com 
C)  MS-Tag/MS-Seq http://prospector.ucsf.edu/ 
D)  PeptideSearch http://www.narrador.embl-heidelberg.de/GroupPages/Homepage.html 
E)  PepFrag http://prowl.rockefeller.edu/PROWL
F) All of the above
G) None of the above

Question 3

What is the main reason for use of mass spectrometry techniques in protein and peptide analysis in drug delivery?

Accepted Answer

A)  Pharmacokinetic (PK-ADM
E)  
B)  Pharmacodynamics (P
D)  
C)  a and b 
D)  None of the above 
A)  Pharmacokinetic (PK-ADM
E)  
B)  Pharmacodynamics (P
D)  
C)  a and b 
D)  None of the above

Question 4

Large biomolecules,molecular masses can be measured to within an accuracy of _____ of the total molecular mass?

Accepted Answer

The answer of Large biomolecules,molecular masses can be measured to...

Question 5

Mass spectrometers can be divided into three fundamental parts,namely the ___,___,and ___.

Accepted Answer

ionization

Question 6

Fill in the blanks: Phosphorylation is associated with respiration and photosynthesis which occurs in _________and _____________.

Accepted Answer

mitochondr

Question 7

Covalent post-translational modifications occurs in a residue of proteome?

Accepted Answer

A) True 
 B)False

Question 8

By which enzyme catalysis,the carboxylation reaction introduces carbon dioxide in the DNA?

Accepted Answer

A)  Cytochrome-P450 
B)  β-glycosidase (Emulsin ) 
C)  Ribulose 1,5-bisphosphate carboxylase (Rubisco). 
D)  None of the above 
A)  Cytochrome-P450 
B)  β-glycosidase (Emulsin ) 
C)  Ribulose 1,5-bisphosphate carboxylase (Rubisco). 
D)  None of the above

Question 9

Proteins and peptides are generally analyzed in ___ conditions and saccharides and oligonucleotides in ___.

Accepted Answer

positive i

Question 10

Post translational modifications of proteins,DNA and RNA substrates occurs on arginine and lysine residues

Accepted Answer

A) True 
 B)False

Question 11

Match the routes of drug administration with their respective areas of action.
Bone marrow

Accepted Answer

A)  Intra-articular 
B)  Intra-thecal 
C)  Intra-peritoneal 
D)  Intra-medullary 
A)  Intra-articular 
B)  Intra-thecal 
C)  Intra-peritoneal 
D)  Intra-medullary

Question 12

What is the most common technique used for protein digestion?

Accepted Answer

A)  Liquid -liquid extraction 
B)  Solid phase extraction 
C)  Trypsin digestion 
D)  Protein precipitation 
A)  Liquid -liquid extraction 
B)  Solid phase extraction 
C)  Trypsin digestion 
D)  Protein precipitation

Question 13

What kind of amino acid residue play an important role in methylation?

Accepted Answer

A)  Valine 
B)  Glycin 
C)  Lysine 
D)  All of the above 
A)  Valine 
B)  Glycin 
C)  Lysine 
D)  All of the above

Question 14

What is mass spectrometry (MS) ?

Accepted Answer

A)  Analytical technique use in separation of compounds 
B)  Analytical technique use in purification of compounds 
C)  Analytical tool used for measuring the molecular mass of a sample 
D)  None of the above 
A)  Analytical technique use in separation of compounds 
B)  Analytical technique use in purification of compounds 
C)  Analytical tool used for measuring the molecular mass of a sample 
D)  None of the above

Question 15

In which chemical process,lipophilic compounds converts into water-soluble compounds for rapid renal excretion to reduce toxicity?

Accepted Answer

A)  Post translational modifications 
B)  Hydroxylation 
C)  Phosphorylation 
D)  Glycosylation 
E)  None of the above 
A)  Post translational modifications 
B)  Hydroxylation 
C)  Phosphorylation 
D)  Glycosylation 
E)  None of the above

Question 16

Hydroxylation reaction causes oxidative degradation of organic compounds in air and it is not extremely important in detoxification for rapid renal excretion.

Accepted Answer

A) True 
 B)False

Question 17

How can mass spectrometry help in proteomics except?

Accepted Answer

A)  Accurate molecular weight measurements 
B)  Amino acid sequencing 
C)  Protein structure 
D)  Reaction monitoring 
A)  Accurate molecular weight measurements 
B)  Amino acid sequencing 
C)  Protein structure 
D)  Reaction monitoring

Question 18

What is "Omics Science"?

Accepted Answer

A)  Biological research ending omics 
B)  Biotransformation of compounds 
C)  a and b 
D)  None of the above 
A)  Biological research ending omics 
B)  Biotransformation of compounds 
C)  a and b 
D)  None of the above

Question 19

In which chemical process co-translational and post-translational modification of proteins occurs in the cell?

Accepted Answer

A)  Hydroxylation 
B)  Phosphorylation 
C)  Acetylation 
D)  None of the above 
A)  Hydroxylation 
B)  Phosphorylation 
C)  Acetylation 
D)  None of the above

Question 20

Genomics,lipidomics,metabolomics,metabonomics,pharmacogenomics,pharmacomicrobiomics,proteomics,psychogenomics,toxicogenomics and nutrigenomics are called as

Accepted Answer

A)  Biological Science 
B)  Omics Sciences 
C)  a and b 
D)  None of the above 
A)  Biological Science 
B)  Omics Sciences 
C)  a and b 
D)  None of the above

Match the ABC transporter with the respective number of TMDs. MRP2

What type of database search programs are used in proteomics analysis?

What is the main reason for use of mass spectrometry techniques in protein and peptide analysis in drug delivery?

Large biomolecules,molecular masses can be measured to within an accuracy of _____ of the total molecular mass?

Mass spectrometers can be divided into three fundamental parts,namely the _,_,and ___.

Fill in the blanks: Phosphorylation is associated with respiration and photosynthesis which occurs in _and _____.

Covalent post-translational modifications occurs in a residue of proteome?

By which enzyme catalysis,the carboxylation reaction introduces carbon dioxide in the DNA?

Proteins and peptides are generally analyzed in _ conditions and saccharides and oligonucleotides in _.

Post translational modifications of proteins,DNA and RNA substrates occurs on arginine and lysine residues

Match the routes of drug administration with their respective areas of action. Bone marrow

What is the most common technique used for protein digestion?

What kind of amino acid residue play an important role in methylation?

What is mass spectrometry (MS) ?

In which chemical process,lipophilic compounds converts into water-soluble compounds for rapid renal excretion to reduce toxicity?

Hydroxylation reaction causes oxidative degradation of organic compounds in air and it is not extremely important in detoxification for rapid renal excretion.

How can mass spectrometry help in proteomics except?

What is "Omics Science"?

In which chemical process co-translational and post-translational modification of proteins occurs in the cell?

Genomics,lipidomics,metabolomics,metabonomics,pharmacogenomics,pharmacomicrobiomics,proteomics,psychogenomics,toxicogenomics and nutrigenomics are called as

Drug Delivery: An Evolving Concept

Barriers to Drug Delivery

Routes of Drug Delivery

Novel Drug Delivery Systems

Controlled Drug Delivery

Multifunctional Nanocarriers for Tumor Drug Delivery and Imaging

Ocular Drug Delivery

Transmucosal Drug Delivery

Transdermal Drug Delivery

Pulmonary and Nasal Drug Delivery

Vaginal Drug Delivery

Drug Delivery to the CNS: Breaking Down the Barrier

Gene Delivery

Peptide and Protein Drug Delivery

Filters

Exam 15: Drug Metabolomics and Proteomics Analysis in Drug Delivery and Discovery

Match the ABC transporter with the respective number of TMDs. MRP2

What type of database search programs are used in proteomics analysis?

What is the main reason for use of mass spectrometry techniques in protein and peptide analysis in drug delivery?

Large biomolecules,molecular masses can be measured to within an accuracy of _____ of the total molecular mass?

Mass spectrometers can be divided into three fundamental parts,namely the ___,___,and ___.

Fill in the blanks: Phosphorylation is associated with respiration and photosynthesis which occurs in _________and _____________.

Covalent post-translational modifications occurs in a residue of proteome?

By which enzyme catalysis,the carboxylation reaction introduces carbon dioxide in the DNA?

Proteins and peptides are generally analyzed in ___ conditions and saccharides and oligonucleotides in ___.

Post translational modifications of proteins,DNA and RNA substrates occurs on arginine and lysine residues

Match the routes of drug administration with their respective areas of action. Bone marrow

What is the most common technique used for protein digestion?

What kind of amino acid residue play an important role in methylation?

What is mass spectrometry (MS) ?

In which chemical process,lipophilic compounds converts into water-soluble compounds for rapid renal excretion to reduce toxicity?

Hydroxylation reaction causes oxidative degradation of organic compounds in air and it is not extremely important in detoxification for rapid renal excretion.

How can mass spectrometry help in proteomics except?

What is "Omics Science"?

In which chemical process co-translational and post-translational modification of proteins occurs in the cell?

Genomics,lipidomics,metabolomics,metabonomics,pharmacogenomics,pharmacomicrobiomics,proteomics,psychogenomics,toxicogenomics and nutrigenomics are called as

Drug Delivery: An Evolving Concept

Barriers to Drug Delivery

Routes of Drug Delivery

Novel Drug Delivery Systems

Controlled Drug Delivery

Multifunctional Nanocarriers for Tumor Drug Delivery and Imaging

Ocular Drug Delivery

Transmucosal Drug Delivery

Transdermal Drug Delivery

Pulmonary and Nasal Drug Delivery

Vaginal Drug Delivery

Drug Delivery to the CNS: Breaking Down the Barrier

Gene Delivery

Peptide and Protein Drug Delivery

Filters

Mass spectrometers can be divided into three fundamental parts,namely the _,_,and ___.

Fill in the blanks: Phosphorylation is associated with respiration and photosynthesis which occurs in _and _____.

Proteins and peptides are generally analyzed in _ conditions and saccharides and oligonucleotides in _.