Question 1

This nephrectomy specimen shows a lesion in the kidney of a 63-year-old man. The lesion is most likely related to

Accepted Answer

A)  a deletion of von Hippel-Lindau (VHL) tumor suppressor gene 
B)  a mutation of myc oncogene 
C)  an amplification of ras oncogene 
D)  a loss of bcl-2 proapoptotic gene 
E)  an aflatoxin related carcinogen 
A)  a deletion of von Hippel-Lindau (VHL) tumor suppressor gene 
B)  a mutation of myc oncogene 
C)  an amplification of ras oncogene 
D)  a loss of bcl-2 proapoptotic gene 
E)  an aflatoxin related carcinogen A

Question 2

The normal glomerular basement membrane is composed of which type of collagen?

Accepted Answer

A)  Type I 
B)  Type II 
C)  Type III 
D)  Type IV 
E)  Type V 
A)  Type I 
B)  Type II 
C)  Type III 
D)  Type IV 
E)  Type V D

Question 3

Which kidney disease characterized by nephrotic syndrome, microscopic hematuria, and glomerular deposits of C3 complement and properdin is caused by an autoantibody called C3 nephritic factor?

Accepted Answer

A)  Membranoproliferative glomerulonephritis type II 
B)  Focal segmental glomerulosclerosis 
C)  Membranous nephropathy 
D)  IgA nephropathy 
E)  Acute postinfectious glomerulonephritis 
A)  Membranoproliferative glomerulonephritis type II 
B)  Focal segmental glomerulosclerosis 
C)  Membranous nephropathy 
D)  IgA nephropathy 
E)  Acute postinfectious glomerulonephritis A

Question 4

A 5-year-old boy is taken to the pediatrician because of generalized facial edema and somnolence. He has been passing dark brown urine. Physical examination reveals hypertension. Urinalysis shows oliguria, hematuria, proteinuria, and red blood cell casts. Which of the following is the most likely diagnosis?

Accepted Answer

A)  Nephritic syndrome 
B)  Nephrotic syndrome 
C)  Rapidly progressive acute renal failure 
D)  Chronic uremia 
E)  Nephrolithiasis 
A)  Nephritic syndrome 
B)  Nephrotic syndrome 
C)  Rapidly progressive acute renal failure 
D)  Chronic uremia 
E)  Nephrolithiasis

Question 5

The PKD1 gene encoding polycystin-1 is a large integral membrane protein. It is typically found in persons who have which of the following diseases?

Accepted Answer

A)  Childhood polycystic kidney disease 
B)  Adult polycystic disease 
C)  Adult onset renal medullary cystic disease 
D)  Glomerulocystic disease 
E)  Acquired renal cystic disease 
A)  Childhood polycystic kidney disease 
B)  Adult polycystic disease 
C)  Adult onset renal medullary cystic disease 
D)  Glomerulocystic disease 
E)  Acquired renal cystic disease

Question 6

A 30-year-old heroin addict who is positive for the human immunodeficiency virus (HIV) is hospitalized because of generalized edema. Laboratory studies show proteinuria, hypoalbuminemia, hyperlipidemia, and lipiduria. Which of the following diseases is most likely to be diagnosed by a biopsy of the kidney?

Accepted Answer

A)  Lipoid nephrosis 
B)  Focal segmental glomerulosclerosis 
C)  Membranous nephropathy 
D)  IgA nephropathy 
E)  Amyloidosis 
A)  Lipoid nephrosis 
B)  Focal segmental glomerulosclerosis 
C)  Membranous nephropathy 
D)  IgA nephropathy 
E)  Amyloidosis

Question 7

Membranoproliferative glomerulonephritis caused by mixed cryoglobulinemia is most often secondary to which of the following diseases?

Accepted Answer

A)  Diabetes mellitus 
B)  Multiple myeloma 
C)  Membranous nephropathy 
D)  Amyloidosis 
E)  Human immunodeficiency virus infection 
A)  Diabetes mellitus 
B)  Multiple myeloma 
C)  Membranous nephropathy 
D)  Amyloidosis 
E)  Human immunodeficiency virus infection

This nephrectomy specimen shows a lesion in the kidney of a 63-year-old man. The lesion is most likely related to

The normal glomerular basement membrane is composed of which type of collagen?

Which kidney disease characterized by nephrotic syndrome, microscopic hematuria, and glomerular deposits of C3 complement and properdin is caused by an autoantibody called C3 nephritic factor?

The PKD1 gene encoding polycystin-1 is a large integral membrane protein. It is typically found in persons who have which of the following diseases?

Membranoproliferative glomerulonephritis caused by mixed cryoglobulinemia is most often secondary to which of the following diseases?

Cell Injury, Cell Death, and Adaptations

Inflammation and Repair

Hemodynamic Disorders, Thromboembolism, and Shock

Diseases of the Immune System

Neoplasia

Genetic and Pediatric Diseases

Environmental and Nutritional Diseases

General Pathology of Infectious Diseases

Blood Vessels

Heart

Hematopoietic and Lymphoid Systems

Lung

Oral Cavity and Gastrointestinal Tract

Liver, Gallbladder, and Biliary Tract

Pancreas

Male Genital System and Lower Urinary Tract

Female Genital System and Breast

Endocrine System

Bones, Joints, and Soft Tissue Tumors

Peripheral Nerves and Muscles

Central Nervous System

Skin

Filters

Exam 13: Kidney and Its Collecting System

This nephrectomy specimen shows a lesion in the kidney of a 63-year-old man. The lesion is most likely related to

The normal glomerular basement membrane is composed of which type of collagen?

Which kidney disease characterized by nephrotic syndrome, microscopic hematuria, and glomerular deposits of C3 complement and properdin is caused by an autoantibody called C3 nephritic factor?

The PKD1 gene encoding polycystin-1 is a large integral membrane protein. It is typically found in persons who have which of the following diseases?

Membranoproliferative glomerulonephritis caused by mixed cryoglobulinemia is most often secondary to which of the following diseases?

Cell Injury, Cell Death, and Adaptations

Inflammation and Repair

Hemodynamic Disorders, Thromboembolism, and Shock

Diseases of the Immune System

Neoplasia

Genetic and Pediatric Diseases

Environmental and Nutritional Diseases

General Pathology of Infectious Diseases

Blood Vessels

Heart

Hematopoietic and Lymphoid Systems

Lung

Oral Cavity and Gastrointestinal Tract

Liver, Gallbladder, and Biliary Tract

Pancreas

Male Genital System and Lower Urinary Tract

Female Genital System and Breast

Endocrine System

Bones, Joints, and Soft Tissue Tumors

Peripheral Nerves and Muscles

Central Nervous System

Skin

Filters