Exam 16: Development of the Urinary System

What renal structure arises via a mesenchymal-to-epithelial transition?

An ultrasound of a 7-month-pregnant woman reveals the presence of oligohydramnios.Closer examination suggests that the fetus has bilateral renal agenesis.What could have led to the development of this congenital anomaly?

A young mother brings her 5-year-old girl who is still in diapers to the pediatrician's office.The mother complains that the infant is constantly wetting her diapers even though the girl is potty-trained.Upon examination,you notice what appears to be urine coming from the vagina through a small orifice located in the upper vaginal wall.What is your initial diagnosis?

Which developing kidney system ultimately becomes the definite kidney in humans?

Mutations in particular genes can cause or increase the risk of specific congenital anomalies of the urogenital system.Which gene when mutated is most likely to be responsible for autosomal dominant polycystic kidney disease?

The collecting tubules of the definitive kidney are derived from what tissue (cells)?

Mutations in particular genes can cause or increase the risk of specific congenital anomalies of the urogenital system.Which gene when mutated is most likely to be responsible for glomerulopathy associated with Denys-Drash syndrome?

A 4-year-old child was diagnosed with nephroblastoma,a kidney tumor.Subsequent genetic analysis of the child showed the presence of a mutation in a gene known to be associated with the development of this tumor but having a required role in renal development.What gene is it?