Exam 10: Genomics

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If two genes show a low,but measurable,frequency of crossing over,this means that

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Which of the following statements about bioinformatics is FALSE?

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What is gene therapy? Describe how gene therapy can be used to correct genetic disorders.

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The idea behind gene therapy is the transfer of copies of normal genes into cells (or people)that carry defective copies of these genes.Once transferred,the normal genes should direct the synthesis of the normal gene product,which in turn produces a normal phenotype.In most cases,cells are removed from the body of the person affected with a specific genetic disorder and modified in the lab.Normal copies of the gene are inserted into these cells using a genetically modified virus,called a vector,to carry these genes.The virus,and the human gene it carries,enters the cell and is inserted into a human chromosome.The gene then becomes part of the genetic information carried by that cell.After gene transfer,the cells are grown in the laboratory and checked to ensure that the normal gene is active and making the normal protein.Then the cells are transferred back into the body.

In order for two genes to be linked,they must be located on the same chromosome.

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The frequency of crossing over between two genes is dependent on the

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The distance between two genes on a linkage map represents

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This is a method of gene mapping using markers that show differences in restriction enzyme cutting sites or differences in the number of repeated DNA sequences.

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The field of proteomics involves ____.

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The human genome contains about ____ billion nucleotides.

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Two linked genes are separated by 25 cM.We would expect to see crossing over between these genes occur _____ of the time.

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What are some of the legal and ethical questions associated with genomics?

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MATCHING Match the appropriate term with the description. -Promoters

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Gene therapy is currently used to treat many genetic disorders.

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Two genes that are genetically linked to each other can be separated by crossing over.

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The markers used in positional cloning are always genes.

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MATCHING Match the appropriate term with the description. -Genomic library

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How can there be so many more proteins produced by our cells compared to the number of genes that we have?

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With linkage maps,

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All of the following provide clues to the locations of genes in a DNA sequence EXCEPT

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MATCHING Match the appropriate term with the description. -Crossing over

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